https://scholars.lib.ntu.edu.tw/handle/123456789/483144
標題: | The relationships among serum glucose, albumin concentrations and carotid atherosclerosis in men with spinal cord injury | 作者: | Wang Y.-H. SSU-YUAN CHEN TZUNG-DAU WANG Hwang B.-S. TIEN-SHANG HUANG TA-CHEN SU |
公開日期: | 2009 | 卷: | 206 | 期: | 2 | 起(迄)頁: | 528-534 | 來源出版物: | Atherosclerosis | 摘要: | Limited information is available that examines the interrelationships between glucose tolerance, serum albumin, subclinical inflammation, and carotid atherosclerosis (CA) in patients with spinal cord injury (SCI). We prospectively recruited 110 male patients with traumatic SCI, 57 with SCI at thoracic level 6 or above (SCI-T6) and 53 with SCI at T7 or below (SCI-T7), and 62 age-matched able-bodied controls from the National Taiwan University Hospital. The associations among glucose levels after oral glucose tolerance tests (OGTT), serum albumin, high-sensitivity C-reactive protein (hs-CRP), and CA in terms of the extracranial carotid artery (ECCA) plaque score and common carotid artery (CCA) intima-media thickness (IMT) were examined. Results showed significantly higher post-challenge glucose levels and carotid plaque scores and lower serum albumin in the SCI-T6 patients. In addition, serum albumin was negatively associated with CA and post-challenge glucose levels. The higher post-challenge glucose levels at 120 min (Glu120) were associated with higher serum hs-CRP levels and lower serum albumin levels. In addition, lower serum albumin levels were associated with a thicker CCA IMT and a higher prevalence of ECCA plaque. Mixed models revealed that body mass index, age, LDL-cholesterol, Glu120, homeostasis model assessment for insulin resistance (HOMA-IR), lower serum albumin and smoking habits were positively associated with CCA IMT. Age, HOMA-IR, LDL-cholesterol, and lower serum albumin were identified as the important factors for the presence of carotid plaque by multiple linear regression analyses. In conclusion, post-challenge hyperglycemia and serum albumin levels are important indicators of CV health in men with SCI. ? 2009 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349428633&doi=10.1016%2fj.atherosclerosis.2009.02.035&partnerID=40&md5=b8ae4c4e31f54bf53d40f10773622ecd https://scholars.lib.ntu.edu.tw/handle/123456789/483144 |
ISSN: | 0021-9150 | DOI: | 10.1016/j.atherosclerosis.2009.02.035 | SDG/關鍵字: | albumin; C reactive protein; glucose; glutamic acid; high density lipoprotein cholesterol; adult; age; albumin blood level; arterial wall thickness; article; atherosclerosis; atherosclerotic plaque; body mass; carotid artery disease; cholesterol blood level; controlled study; disease association; glucose blood level; human; hyperglycemia; impaired glucose tolerance; insulin resistance; major clinical study; male; oral glucose tolerance test; prevalence; priority journal; prospective study; protein blood level; smoking; spinal cord injury; Taiwan; Adult; Blood Glucose; C-Reactive Protein; Carotid Artery Diseases; Carotid Artery, Common; Humans; Insulin Resistance; Male; Middle Aged; Serum Albumin; Spinal Cord Injuries; Taiwan; Tunica Intima; Tunica Media |
顯示於: | 醫學系 |
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