https://scholars.lib.ntu.edu.tw/handle/123456789/483211
標題: | Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy | 作者: | WEN-CHIN WENG Tsui P.-H. CHIA-WEI LIN Lu C.-H. Lin C.-Y. JENG-YI SHIEH FRANK LEIGH LU Ee T.-W. KUAN-WEN WU WANG-TSO LEE |
公開日期: | 2017 | 出版社: | Nature Publishing Group | 卷: | 7 | 期: | 1 | 起(迄)頁: | 4131 | 來源出版物: | Scientific Reports | 摘要: | Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the dystrophic process. A total of 47 participants (40 with DMD and 7 healthy controls) were recruited. Patients were classified into stage 1 (presymptomatic and ambulatory), stage 2 (early nonambulatory), and stage 3 (late nonambulatory). All participants underwent ultrasound examinations on the rectus femoris, tibialis anterior, and gastrocnemius. The results revealed that the ultrasound Nakagami parameter correlated positively with functional severity in the patients with DMD. The median Nakagami parameter of the gastrocnemius muscle increased from 0.50 to 0.85, corresponding to the largest dynamic range between normal and stage 3. The accuracy, sensitivity, and specificity of diagnosing walking function were 85.52%, 76.31%, and 94.73%, respectively. The Nakagami parameter of the rectus femoris and gastrocnemius muscles correlated negatively with the 6-minute walking distance in the ambulatory patients. Therefore, changes in the Nakagami parameter for the gastrocnemius muscle are suitable for monitoring disease progression in ambulatory patients and for predicting ambulation loss. Ultrasound Nakagami imaging shows potential for evaluating patients with DMD. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021675742&doi=10.1038%2fs41598-017-04131-8&partnerID=40&md5=31fba1d2d87f2aa3a2a1e57be6ddc18a https://scholars.lib.ntu.edu.tw/handle/123456789/483211 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-04131-8 | SDG/關鍵字: | adolescent; adult; algorithm; case control study; child; diagnostic imaging; Duchenne muscular dystrophy; echography; human; image processing; nuclear magnetic resonance imaging; pathophysiology; preschool child; sensitivity and specificity; skeletal muscle; young adult; Adolescent; Adult; Algorithms; Case-Control Studies; Child; Child, Preschool; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Sensitivity and Specificity; Ultrasonography; Young Adult |
顯示於: | 醫學系 |
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