https://scholars.lib.ntu.edu.tw/handle/123456789/484318
標題: | Development of a normalization algorithm for array comparative genomic hybridization | 作者: | Singh, S. Chen, H.-I.H. Hsu, F.-H. Tsai, M.-H. Chuang, E.Y. MONG-HSUN TSAI ERIC YAO-YU CHUANG |
公開日期: | 2006 | 起(迄)頁: | 49-50 | 來源出版物: | 2006 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2006 | 摘要: | Genomic instability is one of fundamental factors in tumorigenesis and tumor progression. Many studies have demonstrated that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array Comparative Genomic Hybridization (aCGH), developed based on expression microarray technology, can reveal the chromosomal aberrations in segmental copy at a high-resolution. However, due to the nature of aCGH, many standard expression data processing tools, such as data normalization, often failed to yield satisfactory results. The proposed study demonstrated a novel aCGH normalization procedure, which provides an accurate aCGH data normalization by utilizing the dependency of neighboring probe measurements in aCGH experiments. To facilitate the study, we have developed a Hidden Markov Model (HMM) to simulate a series of aCGH experiment with random DNA copy number alteration. Furthermore, based on this new development, we will establish a user-friendly web system in order to provide convenient aCGH analysis. ?2006 IEEE. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/484318 | DOI: | 10.1109/GENSIPS.2006.353150 | SDG/關鍵字: | Computer systems; DNA; Experiments; Genes; Hidden Markov models; Learning systems; Markov processes; Nucleic acids; Organic acids; Signal processing; Standards; Chromosomal aberration (CA); Comparative genomic hybridization (CGH); Data normalization; DNA copy number; Expression data; Genomic instability; Genomic signal processing; Hidden markov model (HMM); High resolutions; International (CO); Microarray technologies; Probe measurements; Processing tools; Tumor progressions; Tumorigenesis; Web systems; Data processing |
顯示於: | 生醫電子與資訊學研究所 |
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