https://scholars.lib.ntu.edu.tw/handle/123456789/484645
標題: | MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma | 作者: | Huang, C.-T. Oyang, Y.-J. Huang, H.-C. HSUEH-FEN JUAN YEN-JEN OYANG |
公開日期: | 2015 | 卷: | 4 | 來源出版物: | Scientific Reports | 摘要: | Papillary thyroid carcinoma (PTC) is a common endocrine malignancy with low death rate but increased incidence and recurrence in recent years. MicroRNAs (miRNAs) are small non-coding RNAs with diverse regulatory capacities in eukaryotes and have been frequently implied in human cancer. Despite current progress, however, a panoramic overview concerning miRNA regulatory networks in PTC is still lacking. Here, we analyzed the expression datasets of PTC from The Cancer Genome Atlas (TCGA) Data Portal and demonstrate for the first time that immune responses are significantly enriched and under specific regulation in the direct miRNA-target network among distinctive PTC variants to different extents. Additionally, considering the unconventional properties of miRNAs, we explore the protein-coding competing endogenous RNA (ceRNA) and the modulatory networks in PTC and unexpectedly disclose concerted regulation of immune responses from these networks. Interestingly, miRNAs from these conventional and unconventional networks share general similarities and differences but tend to be disparate as regulatory activities increase, coordinately tuning the immune responses that in part account for PTC tumor biology. Together, our systematic results uncover the intensive regulation of immune responses underlain by miRNA-mediated networks in PTC, opening up new avenues in the management of thyroid cancer. ? 2015, Nature Publishing Group. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/484645 | DOI: | 10.1038/srep06495 | SDG/關鍵字: | messenger RNA; microRNA; tumor marker; tumor protein; adult; biosynthesis; carcinoma; cellular immunity; DNA microarray; female; gene expression regulation; gene regulatory network; genetics; human; immunology; male; middle aged; pathology; thyroid tumor; Adult; Biomarkers, Tumor; Carcinoma; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Immunity, Cellular; Male; MicroRNAs; Middle Aged; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Thyroid Neoplasms |
顯示於: | 生醫電子與資訊學研究所 |
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