https://scholars.lib.ntu.edu.tw/handle/123456789/485699
標題: | Treatment and Dosimetric Advantages Between VMAT, IMRT, and Helical TomoTherapy in Prostate Cancer | 作者: | CHIAO-LING TSAI Wu J.-K. Chao H.-L. Tsai Y.-C. CHIA-HSIEN CHENG |
公開日期: | 2011 | 卷: | 36 | 期: | 3 | 起(迄)頁: | 264-271 | 來源出版物: | Medical Dosimetry | 摘要: | We investigated the possible treatment and dosimetric advantage of volumetric modulated arc therapy (VMAT) over step-and-shoot intensity-modulated radiation therapy (step-and-hhoot IMRT) and helical tomotherapy (HT). Twelve prostate cancer patients undergoing VMAT to the prostate were included. Three treatment plans (VMAT, step-and-shoot IMRT, HT) were generated for each patient. The doses to clinical target volume and 95% of planning target volume were both ?78 Gy. Target coverage, conformity index, dose to rectum/bladder, monitor units (MU), treatment time, equivalent uniform dose (EUD), normal tissue complication probability (NTCP) of targets, and rectum/bladder were compared between techniques. HT provided superior conformity and significantly less rectal volume exposed to 65 Gy and 40 Gy, as well as EUD/NTCP of rectum than step-and-shoot IMRT, whereas VMAT had a slight dosimetric advantage over step-and-shoot IMRT. Notably, significantly lower MUs were needed for VMAT (309.7 ± 35.4) and step-and-shoot IMRT (336.1 ± 16.8) than for HT (3368 ± 638.7) (p < 0.001). The treatment time (minutes) was significantly shorter for VMAT (2.6 ± 0.5) than step-and-shoot IMRT (3.8 ± 0.3) and HT (3.8 ± 0.6) (p < 0.001). Dose verification of VMAT using point dose and film dosimetry met the accepted criteria. VMAT and step-and-shoot IMRT have comparable dosimetry, but treatment efficiency is significantly higher for VMAT than for step-and-shoot IMRT and HT. ? 2011 American Association of Medical Dosimetrists. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960923672&doi=10.1016%2fj.meddos.2010.05.001&partnerID=40&md5=3c9cc73cde182fb481fcea9a53390800 https://scholars.lib.ntu.edu.tw/handle/123456789/485699 |
ISSN: | 0958-3947 | DOI: | 10.1016/j.meddos.2010.05.001 | SDG/關鍵字: | aged; article; bladder; cancer radiotherapy; clinical article; controlled study; dosimetry; human; intensity modulated radiation therapy; intermethod comparison; male; priority journal; prostate adenocarcinoma; radiation dose; radiation dose distribution; rectum; step and shoot intensity modulated radiation therapy; tomotherapy; treatment duration; treatment planning; volumetric modulated arc therapy; Aged; Humans; Male; Prostatic Neoplasms; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Image-Guided; Radiotherapy, Intensity-Modulated; Tomography, Spiral Computed |
顯示於: | 腫瘤醫學研究所 |
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