https://scholars.lib.ntu.edu.tw/handle/123456789/485792
標題: | Thermopneumatic suction integrated microfluidic blood analysis system | 作者: | Yang, C.-H. Hsieh, Y.-L. PING-HSIEN TSOU Li, B.-R. |
公開日期: | 2019 | 出版社: | PUBLIC LIBRARY SCIENCE | 卷: | 14 | 期: | 3 | 來源出版物: | PLoS ONE | 摘要: | Blood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood tests is the interference of red blood cells; however, the conventional methods of blood separation are often complicated and time consuming. In this study, we devised a simple but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7 ± 0.3% of the plasma in only 6 min. Parameters, such as flow rate, design of the filter trench, and the relative positions of the filter trench and channel, were optimized through microscopic monitoring. Moreover, this air-difference-driven device uses a cost-effective and easy-to-use heater device that creates a low-pressure environment in the microchannel within minutes. With the aforementioned advantages, this blood separation device could be another platform choice for point-of-care testing. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/485792 | ISSN: | 1932-6203 | DOI: | 70893843 10.1371/journal.pone.0208676 |
SDG/關鍵字: | Article; blood sampling; controlled study; cost effectiveness analysis; equipment design; erythrocyte; flow rate; human; hypobarism; mathematical model; microfluidic analysis; nanofabrication; point of care testing; process design; suction; blood examination; devices; economics; lab on a chip; suction; thermodynamics; time factor; Equipment Design; Hematologic Tests; Humans; Lab-On-A-Chip Devices; Point-of-Care Testing; Suction; Thermodynamics; Time Factors |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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