https://scholars.lib.ntu.edu.tw/handle/123456789/487388
Title: | Thymic carcinoma with autoimmune syndrome: Successful treatment with weekly infusional high-dose 5-fluorouracil and leucovorin | Authors: | CHIH-HUNG HSU KUN-HUEI YEH ANN-LII CHENG |
Issue Date: | 1997 | Journal Volume: | 17 | Journal Issue: | 2B | Start page/Pages: | 1331-1334 | Source: | Anticancer Research | Abstract: | Thymic carcinoma is known for its poor clinical outcome and unsatisfactory response to conventional chemotherapy. A 53-year-old woman was diagnosed as having metastatic thymic carcinoma in 1989. She received systemic chemotherapy containing cisplatin, doxorubicin, and cyclophosphamide, and involved-field radiotherapy. A durable complete remission was achieved and lasted for 4 years. When the disease recurred in 1995, she was found to have an autoimmune syndrome in addition to pleural effusion, a posterior mediastinal mass and a left adrenal mass. The autoimmune manifestations were seen as sclerodenna, high titers of rheumatoid factor and anti-nuclear antibody. We adopted a novel HDFL regimen, which is composed of weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin, for this patient. Complete remission was achieved again, and autoimmune syndrome was well controlled. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030937624&partnerID=40&md5=7746973eff1f67a7094b9aa3ae3245d1 https://scholars.lib.ntu.edu.tw/handle/123456789/487388 |
ISSN: | 0250-7005 | SDG/Keyword: | antinuclear antibody; cisplatin; cyclophosphamide; doxorubicin; fluorouracil; folinic acid; rheumatoid factor; adrenal tumor; adult; article; autoimmunity; cancer recurrence; cancer regression; case report; complication; drug therapy; female; human; human tissue; intravenous drug administration; mediastinum mass; oral drug administration; pleura effusion; priority journal; scleroderma; thymus cancer; Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Thymus Neoplasms |
Appears in Collections: | 腫瘤醫學研究所 |
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