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  1. NTU Scholars
  2. 公共衛生學院
  3. 食品安全與健康研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/490926
Title: Associations between prenatal exposure to bisphenol a and neonatal outcomes in a Taiwanese cohort study: Mediated through oxidative stress?
Authors: Chang C.-H.
Huang Y.-F.
Wang P.-W.
Lai C.-H.
Huang L.-W.
HSIN-CHANG CHEN 
Lin M.-H.
Yang W.
Mao I.-F.
Chen M.-L.
Keywords: Bisphenol A; Causal mediation; Infant; Oxidative stress; Pregnant women
Issue Date: 2019
Publisher: Elsevier Ltd
Journal Volume: 226
Start page/Pages: 290-297
Source: Chemosphere
Abstract: 
This study determined whether maternal bisphenol A (BPA) exposure influences birth outcomes through oxidative stress and estimated the daily intake of BPA through breast milk for infants. One hundred and eighty-six pregnant women without pregnancy complications were enrolled and maternal urine was collected in the third trimester. Postnatal breast milk was collected in the first and third months after delivery. Concentrations of BPA were determined through ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Generalized additive model-penalized regression splines and a multivariable regression model were employed to determine the effects of BPA exposure and oxidative stress levels on birth outcomes. A causal mediation analysis was conducted to clarify the mediation effects of oxidative stress due to maternal BPA exposure on birth outcomes. The daily intake of BPA in breast milk was calculated using probabilistic risk assessment methods. The geometric means (geometric standard deviation) of BPA levels for maternal urine and first- and third-month breast milk were 2.19 (2.88) μg/g creatinine., 1.35 (3.53) ng/g, and 3.17 (2.97) ng/g, respectively. No significant mediation existed among maternal BPA exposure, oxidative stress level, and neonatal head circumference. Three percent of 1-monthold babies and 1% of 3-month-old babies exceeded the BPA tolerable daily intake of 4 μg/kg-bw/day proposed by the European Food Safety Authority. This study revealed the BPA exposure profile for pregnant women and infants in northern Taiwan. The marginally significant correlation between maternal BPA exposure and neonatal head circumference should be considered. ? 2019 Elsevier Ltd
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064008097&doi=10.1016%2fj.chemosphere.2019.03.093&partnerID=40&md5=58c15c6158c6f2c40aa5aa0b6d3bb172
https://scholars.lib.ntu.edu.tw/handle/123456789/490926
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2019.03.093
SDG/Keyword: Liquid chromatography; Mass spectrometry; Phenols; Regression analysis; Risk assessment; Bis-phenol a; Causal mediation; European food safety authorities; Infant; Multivariable regression model; Pregnant woman; Quadrupole time of flight mass spectrometry; Ultra performance liquid chromatography; Oxidative stress; 4,4' isopropylidenediphenol; creatinine; 4,4' isopropylidenediphenol; benzhydryl derivative; phenol derivative; chemical compound; child health; concentration (composition); milk; neonate; oxidative stress; pollution exposure; pregnancy; risk assessment; urine; adult; Article; breast milk; cohort analysis; creatinine blood level; female; head circumference; human; major clinical study; maternal exposure; oxidative stress; perinatal period; pregnancy complication; pregnancy outcome; pregnant woman; prenatal exposure; quadrupole mass spectrometry; risk assessment; Taiwan; Taiwanese; third trimester pregnancy; time of flight mass spectrometry; ultra performance liquid chromatography; breast milk; chemically induced; chemistry; child health; drug effect; high performance liquid chromatography; infant; mass spectrometry; maternal exposure; morphometry; newborn; oxidative stress; pregnancy; prenatal exposure; regression analysis; Taiwan; Adult; Benzhydryl Compounds; Body Weights and Measures; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Infant; Infant Health; Infant, Newborn; Mass Spectrometry; Maternal Exposure; Milk, Human; Oxidative Stress; Phenols; Pregnancy; Prenatal Exposure Delayed Effects; Regression Analysis; Risk Assessment; Taiwan
[SDGs]SDG3
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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