https://scholars.lib.ntu.edu.tw/handle/123456789/494942
標題: | Optimal management of EGFR-mutant non-small cell lung cancer with disease progression on first-line tyrosine kinase inhibitor therapy | 作者: | BIN-CHI LIAO Chia-Chi Lin JIH-HSIANG LEE CHIH-HSIN YANG |
公開日期: | 2017 | 出版社: | Elsevier Ireland Ltd | 卷: | 110 | 起(迄)頁: | 7��13�� | 來源出版物: | Lung Cancer | 摘要: | The first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), gefitinib and erlotinib, and the second-generation EGFR-TKI, afatinib, have all been approved as standard first-line treatments for advanced EGFR-mutant non-small cell lung cancer (NSCLC) based on superior progression-free survival results compared to platinum doublet chemotherapy regimens. Acquired resistance to an EGFR-TKI inevitably develops after a period of effective drug treatment. After tumor progression, many combination therapy regimens that include an EGFR-TKI, or EGFR-TKI monotherapy, have been tested in prospective trials with the aim of extending survival. Third-generation EGFR-TKIs such as osimertinib have been developed with the aim of overcoming the effects of EGFR T790M resistance mutation, which occurs in half of the patients with disease progression on EGFR-TKI therapy. Osimertinib has become the standard treatment in patients for whom tumor re-biopsy reveals an acquired EGFR T790M mutation following EGFR-TKI therapy. Other third-generation EGFR-TKIs, such as olmutinib, EGF816, and ASP8273, are still in the trial phase. ? 2017 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019622634&doi=10.1016%2fj.lungcan.2017.05.009&partnerID=40&md5=8d5c98933633d7627f691b1e50c92552 https://scholars.lib.ntu.edu.tw/handle/123456789/494942 |
ISSN: | 0169-5002 | DOI: | 10.1016/j.lungcan.2017.05.009 | SDG/關鍵字: | afatinib; cetuximab; cytotoxic agent; epidermal growth factor receptor; erlotinib; gefitinib; naquotinib; nazartinib; olmutinib; osimertinib; protein tyrosine kinase inhibitor; rociletinib; antineoplastic agent; epidermal growth factor receptor; protein kinase inhibitor; scatter factor receptor; cancer chemotherapy; cancer combination chemotherapy; cancer survival; cancer therapy; disease course; gene amplification; gene mutation; human; information retrieval; liquid biopsy; lung biopsy; Medline; non small cell lung cancer; priority journal; Review; tumor biopsy; algorithm; disease exacerbation; disease management; drug development; genetics; lung tumor; molecularly targeted therapy; mutation; non small cell lung cancer; pathology; treatment outcome; Algorithms; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Disease Management; Disease Progression; Drug Discovery; Gene Amplification; Humans; Lung Neoplasms; Molecular Targeted Therapy; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Receptor, Epidermal Growth Factor; Treatment Outcome |
顯示於: | 腫瘤醫學研究所 |
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