https://scholars.lib.ntu.edu.tw/handle/123456789/495160
標題: | The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane | 作者: | Rocchi E Khodjakov A Volk E.L CHIH-HSIN YANG Litman T Bates S.E Schneider E. |
公開日期: | 2000 | 出版社: | Academic Press Inc. | 卷: | 271 | 期: | 1 | 起(迄)頁: | 42-46 | 來源出版物: | Biochemical and Biophysical Research Communications | 摘要: | The products of the ABC gene family can be generally classified as either full-transporters of half-transporters. Full-transporters are expressed in the plasma membrane, whereas half-transporters are usually found in intracellular membranes. Recently, an ABC half-transporter, the ABCG2 gene product Breast Cancer/Mitoxantrone Resistance Protein (BCRP/MXR), has been shown to cause mitoxantrone and topotecan resistance. The purpose of this study was to determine the expression and the intracellular localization of this protein in various drug-resistant cell lines. BCRP/MXR expression was determined by Western blot and immunohistochemistry. This protein is highly overexpressed in several drug-resistant cell lines and localizes predominantly to the plasma membrane, instead of to intracellular membranes as seen with all other known half-transporters. Therefore, BCRP/MXR is unique among the ABC half-transporters by being localized to the plasma membrane. (C) 2000 Academic Press. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034728768&doi=10.1006%2fbbrc.2000.2590&partnerID=40&md5=f0817f65c8b36ae0dcf53b56bb2d6e90 https://scholars.lib.ntu.edu.tw/handle/123456789/495160 |
ISSN: | 0006-291X | DOI: | 10.1006/bbrc.2000.2590 | SDG/關鍵字: | ABC transporter; mitoxantrone; topotecan; article; breast cancer; cell membrane; drug resistance; gene overexpression; human; human cell; immunoblotting; immunohistochemistry; intracellular membrane; priority journal; protein expression; protein localization |
顯示於: | 腫瘤醫學研究所 |
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