https://scholars.lib.ntu.edu.tw/handle/123456789/495452
標題: | Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan | 作者: | FEN-YU TSENG Chen Y.-T. Chi Y.-C. PEI-LUNG CHEN WEI-SHIUNG YANG |
公開日期: | 2018 | 出版社: | Lippincott Williams and Wilkins | 卷: | 97 | 期: | 46 | 起(迄)頁: | e13254 | 來源出版物: | Medicine (United States) | 摘要: | Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared the serum fetuin-A concentrations in hyperthyroid patients with those in euthyroid patients. We recruited 30 newly-diagnosed hyperthyroid patients (the HY group) and treated them with anti-thyroid regimens as clinically indicated. We recruited 30 euthyroid individuals (the EU group) as controls. We compared laboratory parameters at the baseline and at 6 months. We then determined the associations between the levels of fetuin-A and free thyroxine (fT4), thyroid-stimulating hormone (TSH), or log transformation of TSH (logTSH). At the baseline, the HY patients had significantly higher serum fetuin-A levels than the EU patients (median [Q1, Q3]: 735.4 [537.9, 843.4]ng/mL vs 561.1[449.2, 670.5] ng/mL, P=.010). At 6 months, the serum fetuin-A levels of the HY patients decreased but were still higher than those of the EU patients (698.4 [627.6, 924.3]ng/mL vs 616.5 [498.2, 727.7]ng/mL, P=.002). At baseline, the serum levels of fetuin-A were negatively associated with logTSH (b=-53.79, P=.010). At 6 months, the levels of fetuin-A were positively associated with fT4 (b=86.91, P=.039), and negatively associated with logTSH (b=-104.28, P<.001). Changes to the levels of fetuin-A within 6 months were negatively associated with changes to logTSH (b=-57.80, P=.019). The negative associations between fetuin-A levels and logTSH at baseline and at 6 months, and the changes during the 6 months remained significant after adjustment for sex and age (b=-51.72, P=.016; b=-103.11, P<.001; and b=-59.36, P=.020, respectively). The patients with hyperthyroidism had higher serum fetuin-A levels than the patients with euthyroidism. In patients with hyperthyroidism, the serum fetuin-A concentrations decreased after the anti-thyroid treatment. In the present study, serum fetuin-A concentrations were negatively associated with logTSH. ? 2018 the Author(s). Published by Wolters Kluwer Health, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056661307&doi=10.1097%2fMD.0000000000013254&partnerID=40&md5=7b5dfb305beab2cb06ad5d82ad695b3b https://scholars.lib.ntu.edu.tw/handle/123456789/495452 |
ISSN: | 0025-7974 | DOI: | 10.1097/MD.0000000000013254 | SDG/關鍵字: | fetuin A; thyrotropin; thyroxine; AHSG protein, human; fetuin A; thyrotropin; thyroxine; adult; Article; clinical article; controlled study; disease association; euthyroidism; female; free thyroxine index; human; hyperthyroidism; male; observational study; priority journal; protein blood level; Taiwan; thyrotropin blood level; blood; euthyroid sick syndrome; hyperthyroidism; Adult; alpha-2-HS-Glycoprotein; Euthyroid Sick Syndromes; Female; Humans; Hyperthyroidism; Male; Taiwan; Thyrotropin; Thyroxine |
顯示於: | 醫學系 |
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