https://scholars.lib.ntu.edu.tw/handle/123456789/495533
標題: | Anaemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: A systematic review and meta-analysis | 作者: | Weng T.-C. CHIA-HSUIN CHANG Dong Y.-H. YI-CHENG CHANG LEE-MING CHUANG |
公開日期: | 2015 | 出版社: | BMJ Publishing Group | 卷: | 5 | 期: | 7 | 起(迄)頁: | e006964 | 來源出版物: | BMJ Open | 摘要: | Objective: To obtain a pooled risk estimate on the long-term impact of anaemia and related nutritional deficiencies in patients receiving Roux-en-Y gastric bypass (RYGB) surgery. Design: Systematic review and meta-analysis. Data sources: MEDLINE, EMBASE and Cochrane databases were searched to identify English reports published before 16 May 2014. Eligibility criteria: Articles with case numbers >100, follow-up period >12 months, and complete data from both before and after surgery were selected. Outcomes of interest were changes in baseline measurements of proportion of patients with anaemia, by haemoglobin, haematocrit, ferritin, iron, vitamin B12 and folate levels. Data collection and analysis: Two reviewers independently reviewed data and selected six prospective and nine retrospective studies with a total of 5909 patients. A random effect model with inverse variance weighting was used to calculate summary estimates of outcomes at 6, 12, 24 and 36 months postoperatively. Results: Proportion of patients with anaemia was 12.2% at baseline, which, respectively, increased to 20.9% and 25.9% at 12 and 24 months follow-up, consistent with decreases in haemoglobin and haematocrit levels. Although the serum iron level did not change substantially after surgery, the frequency of patients with ferritin deficiency increased from 7.9% at baseline to 13.4% and 23.0% at 12 and 24 months, respectively, postoperation. Vitamin B12 deficiency increased from 2.3% at baseline to 6.5% at 12 months after surgery in those subjects receiving RYGB. There was no obvious increase in folate deficiency. Conclusions: RYGB surgery is associated with an increased risk of anaemia and deficiencies of iron and vitamin B12, but not folate. Ferritin is more sensitive when serum iron level is within normal range. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937199758&doi=10.1136%2fbmjopen-2014-006964&partnerID=40&md5=f1fe90f58fc7aeb21872931ae86eff82 https://scholars.lib.ntu.edu.tw/handle/123456789/495533 |
ISSN: | 2044-6055 | DOI: | 10.1136/bmjopen-2014-006964 | SDG/關鍵字: | cyanocobalamin; ferritin; folic acid; hemoglobin; iron; ferritin; iron; anemia; cyanocobalamin deficiency; folic acid deficiency; follow up; hematocrit; human; iron blood level; meta analysis; nutritional deficiency; Review; stomach bypass; systematic review; adverse effects; anemia; blood; complication; gastric bypass surgery; Obesity, Morbid; postoperative period; Vitamin B 12 Deficiency; Anemia; Ferritins; Gastric Bypass; Humans; Iron; Obesity, Morbid; Postoperative Period; Vitamin B 12 Deficiency |
顯示於: | 醫學系 |
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