https://scholars.lib.ntu.edu.tw/handle/123456789/495539
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | Jiang J.-Y. | en_US |
dc.contributor.author | YI-DER JIANG | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.contributor.author | HWANG, JUEY-JEN | en_US |
dc.contributor.author | Lien W.-P. | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.creator | LEE-MING CHUANG;Lien W.-P.;Hwang J.-J.;Chiang F.-T.;Jiang Y.-D.;Jiang J.-Y.;Chang Y.-C. | - |
dc.date.accessioned | 2020-06-01T04:30:32Z | - |
dc.date.available | 2020-06-01T04:30:32Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349857829&doi=10.1253%2fcircj.CJ-09-0228&partnerID=40&md5=ebdf30250b38966c8d3cf7a84c399f2a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495539 | - |
dc.description.abstract | Background: The protective effect of +45T>G polymorphism in the adiponectin gene (ADIPOQ) on coronary artery disease (CAD) has been demonstrated in European populations, so this study investigated the effect of +45T>G polymorphism on the risk of CAD and its interactions with other metabolic risk factors in a Chinese population. Methods and Results: The +45T>G polymorphism (rs2241766) of ADIPOQ was genotyped in 600 patients with angiographically diagnosed CAD and in 718 controls. The G allele at the +45T>G polymorphism was associated with a lower risk of CAD (odds ratio (OR), 0.76; 95% confidence interval (CI), 0.64-0.89; P=0.001). The protective effect of the G allele at +45T>G polymorphism was magnified at blood pressure <140/90 mmHg (OR, 0.65; 95%CI, 0.51-0.82; P=0.0004), but disappeared at blood pressure ?140/90 mmHg (OR, 0.98; 95%CI, 0.76-1.28; P=0.93), indicating an interaction between +45T>G polymorphism and blood pressure on CAD risk (P=0.02 for interaction). A similar interaction was also observed between plasma cholesterol level and the +45T>G polymorphism. Conclusions: An association of ADIPOQ genetic polymorphism with CAD risk is modified by traditional risk factors, such as blood pressure and plasma cholesterol level. | en_US |
dc.relation.ispartof | Circulation Journal | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cholesterol; adipoq gene; adult; allele; article; blood pressure; cardiovascular risk; Chinese; cholesterol blood level; controlled study; coronary artery disease; female; gene; genetic risk; genotype; human; major clinical study; male; risk assessment; risk factor; single nucleotide polymorphism; Adiponectin; Adult; Aged; Asian Continental Ancestry Group; Biological Markers; Blood Pressure; Case-Control Studies; China; Cholesterol; Coronary Artery Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Taiwan | - |
dc.title | Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1253/circj.CJ-09-0228 | - |
dc.identifier.pmid | 19661719 | - |
dc.identifier.scopus | 2-s2.0-70349857829 | - |
dc.relation.pages | 1934-1938 | en_US |
dc.relation.journalvolume | 73 | en_US |
dc.relation.journalissue | 10 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.orcid | 0000-0002-4276-5461 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.orcid | 0000-0001-6437-0455 | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。