https://scholars.lib.ntu.edu.tw/handle/123456789/495577
標題: | Breast-feeding and childhood-onset type 1 diabetes: A pooled analysis of individual participant data from 43 observational studies | 作者: | Cardwell C.R. Stene L.C. Ludvigsson J. Rosenbauer J. Cinek O. Svensson J. Perez-Bravo F. Memon A. Gimeno S.G. Wadsworth E.J.K. Strotmeyer E.S. Goldacre M.J. Radon K. LEE-MING CHUANG Parslow R.C. Chetwynd A. Karavanaki K. Brigis G. Pozzilli P. Urbonaite B. Schober E. Devoti G. Sipetic S. Joner G. Ionescu-Tirgoviste C. De Beaufort C.E. Harrild K. Benson V. Savilahti E. Ponsonby A.-L. Salem M. Rabiei S. Patterson C.C. |
公開日期: | 2012 | 卷: | 35 | 期: | 11 | 起(迄)頁: | 2215-2225 | 來源出版物: | Diabetes Care | 摘要: | OBJECTIVE - To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS - Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. RESULTS - Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for >2 weeks (20 studies; OR = 0.75, 95% CI 0.64- 0.88), the association after exclusive breast-feeding for >3 months was weaker (30 studies;OR = 0.87, 95%CI 0.75 -1.00), and no association was observed after (nonexclusive) breast-feeding for >2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or >3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I 2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for >2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I 2 = 0%). Adjustments for potential confounders altered these estimates very little. CONCLUSIONS - The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies. ? 2012 by the American Diabetes Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868121007&doi=10.2337%2fdc12-0438&partnerID=40&md5=e571014b42bbd5a04d7f936deb1f0db5 https://scholars.lib.ntu.edu.tw/handle/123456789/495577 |
ISSN: | 0149-5992 | DOI: | 10.2337/dc12-0438 | SDG/關鍵字: | adolescent; adult; article; birth weight; breast feeding; child; child health care; clinical assessment; controlled study; data analysis; disease association; human; infant; insulin dependent diabetes mellitus; major clinical study; maternal age; maternal diabetes mellitus; observational study; onset age; preschool child; risk assessment; risk factor; risk reduction; school child; Adolescent; Breast Feeding; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Male |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。