https://scholars.lib.ntu.edu.tw/handle/123456789/495626
標題: | Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population | 作者: | Lin W.H. LEE-MING CHUANG Chen C.H. Yeh J.I. Hsieh P.S. Cheng C.H. Chen Y.T. |
公開日期: | 2006 | 卷: | 49 | 期: | 6 | 起(迄)頁: | 1214-1221 | 來源出版物: | Diabetologia | 摘要: | Aims/hypothesis: The gene encoding solute carrier family 2, facilitated glucose transporter, member 10 (SLC2A10, previously known as glucose transporter 10 [GLUT10]) is a promising candidate gene for type 2 diabetes since it is highly expressed in liver and pancreas and is located on human chromosome region 20q12-q13.1, a region previously shown to harbour type 2 diabetes susceptibility genes. We investigated whether the SLC2A10 gene could be a type 2 diabetes susceptibility gene in the Taiwanese population. Subjects and methods: Sequencing of SLC2A10 gene from 48 diabetic subjects detected short tandem repeat polymorphisms in the promoter region, but did not detect any other sequence variants or new single-nucleotide polymorphisms (SNPs) other than those already in the SNPper database (http://snpper.chip.org) (30 June 2005). Results: Using these genetic polymorphisms, we divided the SLC2A10 gene into four distinct linkage disequilibrium blocks and performed a case-control association study in a group of type 2 diabetes subjects (n=375) and normoglycaemic individuals (n=377). The HapD (A-G-T-C) haplotype in block 3, a rare haplotype, which consisted of four SNPs (rs3092412, rs2235491, rs2425904 and rs1059217), was modestly associated with type 2 diabetes with a haplotype score of -2.95567 (p=0.012 with the haplotype-specific test). Conclusions/interpretation: Our results suggest that SLC2A10 genetic variations do not appear to be major determinants for type 2 diabetes susceptibility in the Taiwanese population. ? Springer-Verlag 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646526010&doi=10.1007%2fs00125-006-0218-3&partnerID=40&md5=e75bac1e5dc69f353811dbd59aa49337 https://scholars.lib.ntu.edu.tw/handle/123456789/495626 |
ISSN: | 0012-186X | DOI: | 10.1007/s00125-006-0218-3 | SDG/關鍵字: | glucose transporter; solute carrier family 2 member 10; unclassified drug; adult; article; case control study; chromosome 20q; controlled study; female; gene; gene expression; gene linkage disequilibrium; gene location; genetic polymorphism; genetic predisposition; genetic variability; haplotype; human; liver; major clinical study; male; non insulin dependent diabetes mellitus; pancreas; priority journal; promoter region; sequence analysis; short tandem repeat; single nucleotide polymorphism; SLC2A10 gene; Taiwan; Aged; Base Sequence; Cholesterol; Diabetes Mellitus, Type 2; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Glucose Transport Proteins, Facilitative; Hemoglobin A, Glycosylated; Humans; Male; Microsatellite Repeats; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Taiwan; Triglycerides; Variation (Genetics) |
顯示於: | 醫學系 |
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