https://scholars.lib.ntu.edu.tw/handle/123456789/495635
標題: | Plasma zinc α2-glycoprotein levels are elevated in smokers and correlated with metabolic syndrome | 作者: | JAW-SHIUN TSAI Chen S.-C. KUO-CHIN HUANG Lue B.-H. Lee L.-T. TAI-YUAN CHIU Chen C.-Y. FEI-RAN GUO LEE-MING CHUANG |
公開日期: | 2015 | 出版社: | Blackwell Publishing Ltd | 卷: | 45 | 期: | 5 | 起(迄)頁: | 452-459 | 來源出版物: | European Journal of Clinical Investigation | 摘要: | Background: Smoking is a strong risk factor of metabolic syndrome. Zinc α2-glycoprotein (ZAG) is a protein involved in metabolic syndrome. This study aims to investigate the effect of smoking on plasma ZAG levels and its relations to metabolic syndrome. Materials and methods: A group of 41 cigarette smokers and 47 non-smokers were enrolled. ZAG levels were measured to correlate to participants' demographic and metabolic parameters. Results: Plasma ZAG levels of smokers were higher than those of controls (P < 0·0001). Plasma ZAG levels were positively correlated with male gender (P = 0·0002), number of cigarettes smoked per day (P < 0·0001), smoking duration in years (P < 0·0001), smoking index (P < 0·0001) and nicotine dependence score (P < 0·0001). In the multiple regression analysis, smoking was a strong independent factor affecting plasma ZAG levels (P = 0·0034). Plasma ZAG levels elevated progressively with the number of metabolic syndrome components (P = 0·0143). In the multiple regression analysis, plasma ZAG was an independent factor for metabolic syndrome. Conclusions: Plasma ZAG levels are high in smokers and correlate with metabolic syndrome. Our results indicate ZAG is an independent risk factor, but also interacted with smoking, for the metabolic syndrome. ? 2015 Stichting European Society for Clinical Investigation Journal Foundation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928370019&doi=10.1111%2feci.12425&partnerID=40&md5=0240651b579cd1d4cd9f3f408e98737c https://scholars.lib.ntu.edu.tw/handle/123456789/495635 |
ISSN: | 0014-2972 | DOI: | 10.1111/eci.12425 | SDG/關鍵字: | alpha2 glycoprotein; unclassified drug; zinc alpha2 glycoprotein; AZGP1 protein, human; carrier protein; glycoprotein; adult; aged; Article; blood level; blood sampling; cardiovascular disease; clinical article; controlled study; demography; diabetes mellitus; dyslipidemia; female; human; hypertension; male; metabolic parameters; metabolic syndrome X; obesity; priority journal; smoking; tobacco dependence; blood; hyperglycemia; hypertriglyceridemia; metabolic syndrome X; middle aged; regression analysis; sex difference; smoking; time; very elderly; young adult; Adult; Aged; Aged, 80 and over; Carrier Proteins; Dyslipidemias; Female; Glycoproteins; Humans; Hyperglycemia; Hypertension; Hypertriglyceridemia; Male; Metabolic Syndrome X; Middle Aged; Obesity; Overweight; Regression Analysis; Sex Factors; Smoking; Time Factors; Tobacco Use Disorder; Young Adult |
顯示於: | 醫學系 |
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