https://scholars.lib.ntu.edu.tw/handle/123456789/495639
標題: | Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan | 作者: | CHING-CHUNG CHANG Huang C.-N. LEE-MING CHUANG |
公開日期: | 1998 | 卷: | 139 | 期: | 1 | 起(迄)頁: | 44-48 | 來源出版物: | European Journal of Endocrinology | 摘要: | Objective: Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD). Genetic susceptibility to autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about the situation in the Chinese population. We have, therefore, investigated the prevalence of anti-thyroid peroxidase (anti-TPO) in type 1 diabetic patients, and compared the effect of anti-glutamate decarboxylase (anti-GAD) on the thyroid autoimmunity in patients with type 1 diabetes mellitus in Taiwan. Subjects and methods: Two hundred and forty-three subjects with type 1 diabetes mellitus and seventy unrelated normal controls were recruited for the detection of anti-TPO. Two hundred and seventeen sera from two hundred and forty-three type 1 diabetic patients were tested for anti-GAD. RIA and immunoprecipitation were used for anti-TPO and anti-GAD detection respectively. Results: The intra-assay and interassay coefficients of variation of anti-TPO detected by the RIA method ranged from 5.5% to 11.1%. Among 243 type 1 diabetic patients, 53 (21.8%) were positive for anti-TPO. Compared with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female:male, 99:91 vs 37:16 respectively). Among the type 1 diabetic patients with thyroid autoimmunity, anti-TPO tended to occur in those of older age or with long-standing disease. The frequency of anti-GAD was 45.6% (99 of 217), without gender preponderance (males:females, 18.0% vs 27.6%). Compared with those with negative anti-GAD, no significant difference of anti-TPO positivity for the type 1 diabetic patients with positive anti-GAD was found. Conclusion: Our data indicated that the RIA method for anti-TPO detection is sensitive and precise for routine clinical use. The presence of anti-TPO in 21.8% of our type 1 diabetic patients confirmed the strong association of ATD and type 1 diabetes mellitus without ethnic differences. The absence of correlation between anti-TPO and anti-GAD in our type 1 diabetic patients suggested genetic heterogeneity in the role of autoimmunity of type 1 diabetes mellitus and ATD among races. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031829670&doi=10.1530%2feje.0.1390044&partnerID=40&md5=66594d337761ecaa82b1f2573846460b https://scholars.lib.ntu.edu.tw/handle/123456789/495639 |
ISSN: | 0804-4643 | DOI: | 10.1530/eje.0.1390044 | SDG/關鍵字: | autoantibody; glutamate decarboxylase; thyroid peroxidase; antibody detection; article; autoimmune disease; clinical trial; controlled study; disease association; ethnic difference; female; genetic heterogeneity; genetic susceptibility; graves disease; hashimoto disease; human; insulin dependent diabetes mellitus; major clinical study; male; priority journal; sex difference; Adolescent; Adult; Aging; Autoantibodies; Autoimmunity; Child; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Iodide Peroxidase; Male; Microsomes; Middle Aged; Sex Characteristics; Taiwan |
顯示於: | 醫學系 |
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