https://scholars.lib.ntu.edu.tw/handle/123456789/495717
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YI-CHENG CHANG | en_US |
dc.contributor.author | Chiu Y.-F. | en_US |
dc.contributor.author | Ho L.L.-T. | en_US |
dc.contributor.author | Ting C.-T. | en_US |
dc.contributor.author | Shih K.-C. | en_US |
dc.contributor.author | Curb J.D. | en_US |
dc.contributor.author | Chen Y.-D.I. | en_US |
dc.contributor.author | HUNG-YUAN LI | en_US |
dc.contributor.author | LEE-MING CHUANG | en_US |
dc.creator | LEE-MING CHUANG;Li H.-Y.;Chen Y.-D.I.;Curb J.D.;Shih K.-C.;Ting C.-T.;Ho L.L.-T.;Chiu Y.-F.;Chang Y.-C. | - |
dc.date.accessioned | 2020-06-01T04:31:18Z | - |
dc.date.available | 2020-06-01T04:31:18Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0946-2716 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77951207164&doi=10.1007%2fs00109-009-0542-4&partnerID=40&md5=9f4b30a32dfa95b9ade0e7363456e0fc | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/495717 | - |
dc.description.abstract | TCF7L2 genetic variants were associated with progression to type 2 diabetes in Europeans. However, the role of TCF7L2 in type 2 diabetes remained uncertain in Chinese. Seventeen tag single nucleotide polymorphisms were genotyped in 1,094 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance family study. At baseline, the rs7903146 T allele in the exon 4 linkage disequilibrium (LD) block were associated with lower insulinogenic index at 60 min (P = 0.01), while the rs290481 G allele near the 3′ end was associated with higher 2-h post-challenge glucose (P = 0.003) and insulin concentration (P = 0.02), elevated systolic (P = 0.01) and diastolic blood pressure (P = 0.006), lower waist circumference (P = 0.01), and increased steady-state plasma glucose (SSPG) concentration measured with modified insulin suppression test (P = 0.02). Over an average follow-up period of 5.43 years, participants with the rs7903146 T allele or variants in the same LD block, but not those with the rs290481 G allele, were more likely to progress to diabetes (hazard ratio = 2.61, 95% confidence interval, 1.27-5.39, P = 0.009) than were non-carriers. TCF7L2 gene expression was inversely associated with SSPG in human visceral (r = -0.73, P = 0.006) and subcutaneous adipose tissue (r = -0.62, P = 0.03). TCF7L2 may exert pleiotropic effects on insulin secretion or insulin resistance. However, only variants associated with impaired β-cell function predict progression to diabetes in Chinese. ? 2009 Springer-Verlag. | - |
dc.relation.ispartof | Journal of Molecular Medicine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | transcription factor 7 like 2; adult; article; cell function; Chinese; controlled study; diastolic blood pressure; exon; female; gene frequency; gene linkage disequilibrium; genetic association; genetic risk; genetic variability; genotype; glucose blood level; human; hypertension; incidence; insulin release; insulin resistance; insulin sensitivity; major clinical study; male; non insulin dependent diabetes mellitus; pancreas islet beta cell; population genetics; single nucleotide polymorphism; systolic blood pressure; Adult; Asian Continental Ancestry Group; Cohort Studies; Diabetes Mellitus, Type 2; Disease Progression; Family; Female; Genetic Variation; Humans; Incidence; Insulin; Insulin Resistance; Male; Middle Aged; Polymorphism, Single Nucleotide; TCF Transcription Factors | - |
dc.title | TCF7L2 genetic variants and progression to diabetes in the Chinese population: Pleiotropic effects on insulin secretion and insulin resistance | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s00109-009-0542-4 | - |
dc.identifier.pmid | 19806338 | - |
dc.identifier.scopus | 2-s2.0-77951207164 | - |
dc.relation.pages | 183-192 | - |
dc.relation.journalvolume | 88 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Medical Genomics and Proteomics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-8077-5011 | - |
crisitem.author.orcid | 0000-0001-9644-2855 | - |
crisitem.author.orcid | 0000-0003-0978-2662 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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