https://scholars.lib.ntu.edu.tw/handle/123456789/495787
標題: | National Differences in Remission of Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity (BMI 30–35 kg/m2) | 作者: | Chong K. Ikramuddin S. Lee W.-J. Billington C.J. Bantle J.P. Wang Q. Thomas A.J. Connett J.E. Leslie D.B. Inabnet W.B. III, Jeffery R.W. Sarr M.G. Jensen M.D. Vella A. Ahmed L. Belani K. Schone J.L. Olofson A.E. Bainbridge H.A. Laqua P.S. Korner J. LEE-MING CHUANG |
公開日期: | 2017 | 出版社: | Springer New York LLC | 卷: | 27 | 期: | 5 | 起(迄)頁: | 1189-1195 | 來源出版物: | Obesity Surgery | 摘要: | Background: The purpose of this study is to compare effects of different nations on Roux-en-Y gastric bypass (RYGB) vs. intensive medical management (IMM) in achieving remission of type 2 diabetes mellitus (T2DM). Materials and Methods: Between April 2008 and December 2011, this randomized, controlled clinical trial was conducted at four teaching hospitals in the United States and Taiwan involving 71 participants with mild obesity (BMI 30–35?kg/m2). Thirty-six of 71 participants were randomly assigned to the RYGB group, and the others were in IMM group. Partial or complete remission of T2DM was defined as blood HbA1c?6.5?% (48?mmol/mol) or <6?% (42?mmol/mol) without any antihyperglycemic medication for at least 1-year duration, respectively. Results: At baseline, Taiwanese participants had a lower BMI, younger age, and shorter duration of T2DM than American participants. At 24?months, weight loss was greater in the RYGB group in both populations than in the IMM group. No IMM participant of either population had partial or complete remission of T2DM. In the RYGB group, a substantial proportion of the subjects achieved complete or partial remission (57?% in Taiwanese and 27?% in American participants, P?=?0.08). Logistic regression revealed stimulated C-peptide (Odds ratio 2.22, P?=?0.02) but not nationality as a significant predictor of diabetes remission. Conclusion: Adding RYGB to lifestyle and medical management was associated with a greater likelihood of remission of T2DM in both Taiwanese and American subjects with mild obesity with type 2 diabetes. Residual beta-cell function at baseline appears to be the major factor predicting remission of T2DM. Trial registry number: clinicaltrials.gov Identifier: NCT00641251. ? 2016, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992411974&doi=10.1007%2fs11695-016-2433-4&partnerID=40&md5=9f5f2047bf093ca6db9a471726bac057 https://scholars.lib.ntu.edu.tw/handle/123456789/495787 |
ISSN: | 0960-8923 | DOI: | 10.1007/s11695-016-2433-4 | SDG/關鍵字: | C peptide; glucose; hemoglobin A1c; metformin; sulfonylurea; antidiabetic agent; C peptide; adult; American; Article; body mass; cell function; controlled study; disease duration; female; follow up; glycemic control; groups by age; human; lifestyle modification; major clinical study; male; multicenter study; non insulin dependent diabetes mellitus; obesity; postoperative period; priority journal; race difference; randomized controlled trial; remission; Roux-en-Y gastric bypass; Taiwan; Taiwanese; teaching hospital; United States; waist circumference; weight reduction; body mass; comparative study; complication; gastric bypass surgery; lifestyle; middle aged; non insulin dependent diabetes mellitus; obesity; procedures; time factor; treatment outcome; Adult; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Hypoglycemic Agents; Life Style; Male; Middle Aged; Obesity; Remission Induction; Taiwan; Time Factors; Treatment Outcome; United States |
顯示於: | 醫學系 |
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