https://scholars.lib.ntu.edu.tw/handle/123456789/495790
標題: | Impact of apolipoprotein A5 polymorphisms on insulin sensitivity and β-cell function | 作者: | Chiu K.C. Chiu Y.-F. Boyadjian A.A. Fernando S. Kwan C. LEE-MING CHUANG |
公開日期: | 2005 | 卷: | 30 | 期: | 4 | 起(迄)頁: | 328-332 | 來源出版物: | Pancreas | 摘要: | Objectives: Alternation in lipid metabolism can affect both insulin sensitivity and β-cell function. Apolipoprotein A5 (APOA5) is an important determinant of lipid metabolism. The impact of the APOA5 gene on insulin sensitivity and β-cell function has not been examined. Methods: We examined the influence of 2 amino acid polymorphisms (V150M and G182C) in the APOA5 gene on insulin sensitivity and β-cell function in 67 glucose-tolerant white subjects. Insulin sensitivity index (ISI) and first- and second-phase insulin responses (1stIR and 2ndIR) were assessed using a hyperglycemic clamp technique. Results: We identified 59 VV and 8 VM subjects, and none had either the GC or CC genotype. Although no association was found with fasting lipid profile and plasma glucose concentrations during oral glucose tolerance test, the V150M was associated with higher 1stIR (P = 0.0010) and 2ndIR (P = 0.0016) and lower ISI (P = 0.0135). The associations of this polymorphism with 1stIR (P = 0.0081) and 2ndIR (P = 0.0087) were independent of sex, age, and body mass index, but not ISI. Conclusions: The V150M polymorphism had an independent influence on 1stIR and 2ndIR. Although the biologic consequence of this polymorphism remains to be determined, the V150M polymorphism in the APOA5 gene is a genetic marker for β-cell function. Copyright ? 2005 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-17844385850&doi=10.1097%2f01.mpa.0000163176.59920.b1&partnerID=40&md5=3a23715673b5cc73fef03040769a211b https://scholars.lib.ntu.edu.tw/handle/123456789/495790 |
ISSN: | 0885-3177 | DOI: | 10.1097/01.mpa.0000163176.59920.b1 | SDG/關鍵字: | apolipoprotein A5; genomic DNA; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; adult; age; apoa5 gene; article; body mass; Caucasian; controlled study; DNA polymorphism; female; gene; genetic marker; genotype; glucose clamp technique; glucose tolerance; human; human cell; hyperglycemia; insulin sensitivity; lipid metabolism; male; non insulin dependent diabetes mellitus; normal human; nucleotide sequence; oral glucose tolerance test; pancreas islet beta cell; polymerase chain reaction; priority journal; restriction fragment length polymorphism; sex difference; single nucleotide polymorphism; Adult; Apolipoproteins; Apolipoproteins A; European Continental Ancestry Group; Female; Genotype; Glucose Clamp Technique; Humans; Insulin Resistance; Insulin-Secreting Cells; Male; Polymorphism, Genetic |
顯示於: | 醫學系 |
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