https://scholars.lib.ntu.edu.tw/handle/123456789/495851
標題: | Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan: A multivariate twin/sibling analysis | 作者: | Liu P.-H. YI-DER JIANG WEI J. CHEN CHING-CHUNG CHANG Lee T.-C. Sun H.S. LEE-MING CHUANG |
公開日期: | 2008 | 卷: | 11 | 期: | 5 | 起(迄)頁: | 495-504 | 來源出版物: | Twin Research and Human Genetics | 摘要: | Circulating levels of leptin and adiponectin are closely associated with obesity. However, it is not known whether there are common shared genes or environment exerting influences on the levels of leptin, adiponectin, and BMI. We aimed to assess the relative contribution of genes and environment to adiponectin, leptin, and BMI individually as well as simultaneously to the three measures. Our subjects included a total of 228 twin/sibling pairs aged 12 to 18 (130 monozygotic twins, 68 dizygotic twins and 30 sibling pairs) were recruited from the middle schools. Multivariate analyses were applied to twin/sibling data using structural equation modeling. The results showed that intraclass correlations for adiponectin, leptin and BMI were higher in the MZ twins than those in the DZ/SP group. The relative contribution of genes to adiponectin (39%) was comparable to those of shared environment (40%). In contrast, leptin and BMI were influenced mostly by genes (74% and 89%, respectively). The multivariate genetic analyses showed that a latent factor underlying the three measures was identified, with BMI being equivalent to this latent factor. The BMI-dependent genetic factor explains only 15% and 34% of variation of adiponectin and leptin, respectively. These data indicate a differential contribution of genetic factors for the variation of adiponectin, leptin and BMI. More importantly, only a small portion of the genetic influences on adiponectin and leptin was attributed to BMI. Our findings provided more insight into the com - plex regulation of adiponectin and leptin in obesity. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-56749156946&doi=10.1375%2ftwin.11.5.495&partnerID=40&md5=8c6640b314d2e0accd7ea79f13961b35 https://scholars.lib.ntu.edu.tw/handle/123456789/495851 |
ISSN: | 1832-4274 | DOI: | 10.1375/twin.11.5.495 | SDG/關鍵字: | adiponectin; leptin; adolescent; adult; article; blood sampling; body mass; body weight; confidence interval; correlation coefficient; dizygotic twins; environmental factor; enzyme regulation; female; gene control; genetic analysis; genetic correlation; genetic variability; genetics; heredity; human; male; monozygotic twins; multivariate analysis; obesity; phenotype; priority journal; questionnaire; sibling; structural equation modeling; Taiwan; univariate analysis; Adiponectin; Adolescent; Body Composition; Body Mass Index; Environment; Female; Humans; Leptin; Male; Multivariate Analysis; Siblings; Taiwan; Twins, Dizygotic; Twins, Monozygotic |
顯示於: | 醫學系 |
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