https://scholars.lib.ntu.edu.tw/handle/123456789/496233
標題: | Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure | 作者: | Hsueh Y.-M. Wu W.-L. Huang Y.-L. Chiou H.-Y. CHIN-HSIAO TSENG Chen C.-J. |
公開日期: | 1998 | 卷: | 141 | 期: | 2 | 起(迄)頁: | 249-257 | 來源出版物: | Atherosclerosis | 摘要: | To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex- matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose- response relationship with arsenic-related ISHD was observed for serum level of α- and β-carotene, but not for serum levels of retinol, lycopene and α- tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032403039&doi=10.1016%2fS0021-9150%2898%2900178-6&partnerID=40&md5=9324986031065ca34f7b3e576e75da1c https://scholars.lib.ntu.edu.tw/handle/123456789/496233 |
ISSN: | 0021-9150 | DOI: | 10.1016/S0021-9150(98)00178-6 | SDG/關鍵字: | arsenic; carotene; well water; alcohol consumption; article; blood sampling; body mass; cigarette smoking; fluid intake; high performance liquid chromatography; human; human cell; ischemic heart disease; long term exposure; malignant transformation; priority journal; risk assessment; risk factor; taiwan; Adult; Alcohol Drinking; Antioxidants; Arsenic; beta Carotene; Carotenoids; Chromatography, High Pressure Liquid; Humans; Multivariate Analysis; Myocardial Ischemia; Questionnaires; Risk Factors; Smoking; Socioeconomic Factors; Taiwan; Time Factors; Vitamin A; Vitamin E; Water Supply |
顯示於: | 醫學系 |
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