https://scholars.lib.ntu.edu.tw/handle/123456789/496609
Title: | Diabetes and thyroid cancer risk: Literature review | Authors: | SHYANG-RONG SHIH WEI-YIH CHIU TIEN-CHUN CHANG CHIN-HSIAO TSENG |
Issue Date: | 2012 | Journal Volume: | 2012 | Start page/Pages: | 578285 | Source: | Experimental Diabetes Research | Abstract: | Diabetic patients have a higher risk of various types of cancer. However, whether diabetes may increase the risk of thyroid cancer has not been extensively studied. This paper reviews and summarizes the current literature studying the relationship between diabetes mellitus and thyroid cancer, and the possible mechanisms linking such an association. Epidemiologic studies showed significant or nonsignificant increases in thyroid cancer risk in diabetic women and nonsignificant increase or no change in thyroid cancer risk in diabetic men. A recent pooled analysis, including 5 prospective studies from the USA, showed that the summary hazard ratio (95 confidence interval) for women was 1.19 (0.84-1.69) and was 0.96 (0.65-1.42) for men. Therefore, the results are controversial and the association between diabetes and thyroid cancer is probably weak. Further studies are necessary to confirm their relationship. Proposed mechanisms for such a possible link between diabetes and thyroid cancer include elevated levels of thyroid-stimulating hormone, insulin, glucose and triglycerides, insulin resistance, obesity, vitamin D deficiency, and antidiabetic medications such as insulin or sulfonylureas. Copyright ? 2012 Shyang-Rong Shih et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863637929&doi=10.1155%2f2012%2f578285&partnerID=40&md5=d305f10546bb268917b3b09773367296 https://scholars.lib.ntu.edu.tw/handle/123456789/496609 |
ISSN: | 1687-5214 | DOI: | 10.1155/2012/578285 | SDG/Keyword: | glucose; metformin; triacylglycerol; antidiabetic agent; insulin; antineoplastic activity; cancer epidemiology; cancer risk; diabetes mellitus; disease association; hazard ratio; human; priority journal; review; sex difference; thyroid cancer; aged; body mass; diabetes mellitus; female; male; middle aged; proportional hazards model; prospective study; risk; theoretical model; thyroid tumor; Aged; Body Mass Index; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Models, Theoretical; Proportional Hazards Models; Prospective Studies; Risk; Sex Factors; Thyroid Neoplasms |
Appears in Collections: | 醫學系 |
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