https://scholars.lib.ntu.edu.tw/handle/123456789/496873
標題: | Peripheral vasculopathy in rats induced by humic acids | 作者: | Lu F.J. TIEN-SHANG HUANG Lin Y.S. Pang V.F. VICTOR FEI PANG |
公開日期: | 1994 | 卷: | 8 | 期: | 3 | 起(迄)頁: | 223-228 | 來源出版物: | Applied Organometallic Chemistry | 摘要: | Adult male Wistar rats averaging 380 g in weight were injected with single doses (100 mg kg?1 body weight) of humic acids intraperitoneally. ‘Black tails’ were noticed 12 days later. In severely affected regions, thrombosis with mild to moderate acute necrotizing vasculitis was seen in most of the blood vessels located in the dermis, subcutaneous fat and muscle. These blood vessels were markedly dilated. Frequently, colonies of a shortrod bacterium of varying sizes were observed in necrotic tissues. There was mild to moderate edema and minimal accumulation of mast cells and macrophages in the dermis. Acute fat necrosis with fibrin deposition was also seen in the subcutaneous fat. Based on the pathological findings, we diagnosed that the tails of Wistar rats which had been injected with humic acids had severe multifocal thrombosis and mild to moderate, multifocal, acute necrotizing vasculitis with bacterial colonization, mild dermatitis, and fat necrosis. The relevance of these observations to the discussions on arsenic as an etiological factor of human Blackfoot disease is examined. Copyright ? 1994 John Wiley & Sons, Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989559274&doi=10.1002%2faoc.590080311&partnerID=40&md5=b657a5a9a29e38660f9c0c354bdb0fa4 https://scholars.lib.ntu.edu.tw/handle/123456789/496873 |
ISSN: | 0268-2605 | DOI: | 10.1002/aoc.590080311 |
顯示於: | 醫學系 |
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