https://scholars.lib.ntu.edu.tw/handle/123456789/499645
標題: | Transient analysis of streptavidin-biotin complex detection using an IGZO thin film transistor-based biosensor integrated with a microfluidic channel | 作者: | Chen, T.-Y. Yang, T.-H. Wu, N.-T. Chen, Y.-T. JIAN-JANG HUANG |
關鍵字: | Biochemical reactions; Biosensors; Microfluidic channels; Thin-film transistors | 公開日期: | 2017 | 卷: | 244 | 起(迄)頁: | 642-648 | 來源出版物: | Sensors and Actuators, B: Chemical | 摘要: | We demonstrated an integrated biosensor with a thin film transistor for recording electrical charges carried by bio-molecules and a microfluidic channel for detecting diffusion properties of the target solution. Using streptavidin and biotin as examples, the sensor is able to detect the binding interaction of streptavidin-biotin complexes by monitoring the transient responses of the transistor current. Our approach can be applied to the field of detection of protein–protein interactions. © 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009083401&doi=10.1016%2fj.snb.2017.01.050&partnerID=40&md5=39c0b406dd829cba13c57839a33288c3 | DOI: | 10.1016/j.snb.2017.01.050 | SDG/關鍵字: | Binding energy; Biosensors; Coenzymes; Complexation; Fluidic devices; Microfluidics; Proteins; Semiconducting organic compounds; Thin film transistors; Thin films; Transient analysis; Transistors; Binding interaction; Biochemical reactions; Diffusion properties; Electrical charges; Integrated biosensor; Microfluidic channel; Protein interaction; Streptavidin-biotin complex; Thin film circuits |
顯示於: | 電機工程學系 |
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