https://scholars.lib.ntu.edu.tw/handle/123456789/501165
標題: | Bifunctional Cd<inf>2</inf>O<inf>3</inf>/C nanoshells for MR imaging and NIR therapeutic applications | 作者: | Huang, C.-C. Su, C.-H. Li, W.-M. Liu, T.-Y. Chen, J.-H. Yeh, C.-S. JYH-HORNG CHEN |
公開日期: | 2009 | 卷: | 19 | 期: | 2 | 起(迄)頁: | 249-258 | 來源出版物: | Advanced Functional Materials | 摘要: | This paper reports dual function Gd2O3/C nanoshells for application in MR contrast images and NIR-triggered killing cancer cells. The nanoshells are prepared using biological gelatin particles as core templates through a two-step thermal treatment The surfaces of the nanoshells can be readily modified by poly(styrene-alt-maleic acid) (PSMA) polymer to improve their water-dispersible properties and increase their biocompatibility. The Gd2O3/C nanoshells show brightened images of kidney cortex and liver in mice, whereas the Gd2O3/C @ PSMA nanoshells show a darkened liver signal. The biodistribution is measured as a function of time and shows that the nanoshells circulate in the vessels and are cleared out gradually from organs. The graphite carbon coated on the Gd2O 3 nanoshells displays absorbance in the near-IR (NIR) region. A large extinction coefficient is obtained, indicating the potential of the nanoshells as photothermal agents. The Gd2O3/C @ PSMA nanoshells conjugated with anti-epithermal growth factor receptor antibodies are used for targeting and destroying A549 lung cancer cells by means of NIR-triggered killing capability. Both laser power density and material dose dependence are investigated to evaluate photothermolysis in cancer cells. ? 2009 WILEY-VCH Verlag GmbH & Co. KGaA. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/501165 | DOI: | 10.1002/adfm.200801454 | SDG/關鍵字: | Biocompatibility; Gadolinium; Graphite; Heat treatment; Infrared devices; Laser surgery; Liver; Nanostructures; Probability density function; Styrene; Water treatment; Absorbance; Bifunctional; Bio distributions; Cancer cells; Dose dependences; Dual functions; Epithermal; Extinction co-efficient; Function of time; Graphite carbons; Growth factors; Laser power densities; Lung cancer cells; Mr imaging; Nanoshells; Photo thermals; Photothermolysis; Poly (styrene alt maleic acid); Therapeutic applications; Thermal treatments; Water-dispersible; Nanostructured materials |
顯示於: | 電機工程學系 |
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