https://scholars.lib.ntu.edu.tw/handle/123456789/501380
標題: | Design and In Vivo Verification of a CMOS Bone-Guided Cochlear Implant Microsystem. | 作者: | Qian, Xin-Hong Wu, Yi-Chung Yang, Tzu-Yi Cheng, Cheng-Hsiang Chu, Hsing-Chien Cheng, Wan-Hsueh Yen, Ting-Yang Lin, Tzu-Han Lin, Yung-Jen Lee, Yu-Chi Chang, Jia-Heng Lin, Shih-Ting Li, Shang-Hsuan Wu, Tsung-Chen Huang, Chien-Chang Wang, Sung-Hao Lee, Chia-Fone Yang, Chia-Hsiang Hung, Chung-Chih Chi, Tai-Shih Ker, Ming-Dou Wu, Chung-Yu CHIEN-HAO LIU |
關鍵字: | Active rectifier; bone-guided; cochlear implant; implantable medical devices; inductive link power supply | 公開日期: | 2019 | 卷: | 66 | 期: | 11 | 起(迄)頁: | 3156-3167 | 來源出版物: | IEEE Trans. Biomed. Engineering | 摘要: | To develop and verify a CMOS bone-guided cochlear implant (BGCI) microsystem with electrodes placed on the bone surface of the cochlea and the outside of round window for treating high-frequency hearing loss. Methods: The BGCI microsystem consists of an external unit and an implanted unit. The external system-on-chip is designed to process acoustic signals through an acquisition circuit and an acoustic DSP processor to generate stimulation patterns and commands that are transmitted to the implanted unit through a 13.56 MHz wireless power and bidirectional data telemetry. In the wireless power telemetry, a voltage doubler/tripler (2X/3X) active rectifier is used to enhance the power conversion efficiency and generate 2 and 3 V output voltages. In the wireless data telemetry, phase-locked loop based binary phase-shift keying and load-shift keying modulators/demodulators are adopted for the downlink and uplink data through high-Q coils, respectively. The implanted chip with four-channel high-voltage-tolerant stimulator generates biphasic stimulation currents up to 800 μA. Results: Electrical tests on the fabricated BGCI microsystem have been performed to verify the chip functions. The in vivo animal tests in Guinea pigs have shown the evoked third wave of electrically evoked auditory brainstem response waveforms. It is verified that auditory nerves can be successfully stimulated and acoustic hearing can be partially preserved. Conclusion and Significance: Different from traditional cochlear implants, the proposed BGCI microsystem is less invasive, preserves partially acoustic hearing, and provides an effective alternative for treating high-frequency hearing loss. © 1964-2012 IEEE. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/501380 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073656106&doi=10.1109%2fTBME.2019.2901374_rfseq1&partnerID=40&md5=69d8d91d0995b9e8f252d7182ac6e86e |
ISSN: | 00189294 | DOI: | 10.1109/TBME.2019.2901374_rfseq1 | SDG/關鍵字: | Audition; CMOS integrated circuits; Cochlear implants; Electric power systems; Integrated circuit design; Mammals; Microsystems; Signal processing; System-on-chip; Telemetering equipment; Active rectifiers; Auditory brainstem response; High voltage tolerant; Implantable medical devices; Inductive link; Power conversion efficiencies; Stimulation pattern; Wireless power telemetries; Electric rectifiers; acoustics; animal experiment; Article; cochlea; cochlear nerve; electric potential; evoked brain stem auditory response; guinea pig; high frequency hearing loss; in vivo study; nonhuman; scala tympani; signal noise ratio; speech intelligibility; telemetry; animal; cochlea prosthesis; cochlear implantation; devices; equipment design; human; microtechnology; physiology; semiconductor; surgery; Animals; Cochlea; Cochlear Implantation; Cochlear Implants; Cochlear Nerve; Equipment Design; Guinea Pigs; Humans; Microtechnology; Semiconductors |
顯示於: | 電機工程學系 |
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