https://scholars.lib.ntu.edu.tw/handle/123456789/503540
標題: | Recent hepatitis C virus infections in HIV-infected patients in Taiwan: Incidence and risk factors | 作者: | HSIN-YUN SUN SUI-YUAN CHANG Yang Z.-Y. Lu C.-L. Wu H. Yeh C.-C. Liu W.-C. Hsieh C.-Y. CHIEN-CHING HUNG SHAN-CHWEN CHANG |
公開日期: | 2012 | 卷: | 50 | 期: | 3 | 起(迄)頁: | 781-787 | 來源出版物: | Journal of Clinical Microbiology | 摘要: | Outbreaks of sexually transmitted hepatitis C virus (HCV) infections have been recently reported in HIV-infected men who have sex with men (MSM) in Europe, Australia, and North America. Little is known concerning whether this also occurs in other Asia- Pacific countries. Between 1994 and 2010, a prospective observational cohort study was performed to assess the incidence of recent HCV seroconversion in 892 HIV-infected patients (731 MSM and 161 heterosexuals) who were not injecting drug users. A nested case-control study was conducted to identify associated factors with recent HCV seroconversion, and phylogenetic analysis was performed using NS5B sequences amplified from seroconverters. During a total followup duration of 4,270 person-years (PY), 30 patients (3.36%) had HCV seroconversion, with an overall incidence rate of 7.03 per 1,000 PY. The rate increased from 0 in 1994 to 2000 and 2.29 in 2001 to 2005 to 10.13 per 1,000 PY in 2006 to 2010 (P<0.05). After adjustment for age and HIV transmission route, recent syphilis remained an independent factor associated with HCV seroconversion (odds ratio, 7.731; 95% confidence interval, 3.131 to 19.086; P<0.01). In a nested case-control study, seroconverters had higher aminotranferase levels and were more likely to have CD4?200 cells/ μl and recent syphilis than nonseroconverters (P<0.05). Among the 21 patients with HCV viremia, phylogenetic analysis revealed 7 HCV transmission clusters or pairs (4 within genotype 1b, 2 within genotype 2a, and 1 within genotype 3a). The incidence of HCV seroconversion that is associated with recent syphilis is increasing among HIV-infected patients in Taiwan. Copyright ? 2012, American Society for Microbiology. All Rights Reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503540 | ISSN: | 0095-1137 | DOI: | 10.1128/JCM.06014-11 | SDG/關鍵字: | aminotransferase; antiretrovirus agent; nonstructural protein 5B; adult; article; cohort analysis; controlled study; drug use; female; genotype; hepatitis C; Hepatitis C virus; heterosexuality; hospital based case control study; human; human cell; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; infection risk; major clinical study; male; male homosexual; nonhuman; nucleotide sequence; observational study; phylogeny; priority journal; prospective study; risk assessment; risk factor; seroconversion; syphilis; Taiwan; viremia; virus transmission; Adult; Case-Control Studies; Cluster Analysis; Cohort Studies; Genotype; Hepacivirus; Hepatitis C; HIV Infections; Humans; Incidence; Male; Middle Aged; Molecular Sequence Data; Phylogeny; Prospective Studies; Risk Factors; Sequence Analysis, DNA; Sequence Homology; Taiwan; Viral Nonstructural Proteins |
顯示於: | 醫學檢驗暨生物技術學系 |
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