https://scholars.lib.ntu.edu.tw/handle/123456789/503547
標題: | Surveillance of HIV type 1 recent infection and molecular epidemiology among different risk behaviors between 2007 and 2009 after the HIV type 1 CRF07-BC outbreak in Taiwan | 作者: | Kao C.-F. SUI-YUAN CHANG Hsia K.-T. Chang F.-Y. Yang C.-H. Liu H.-R. Fu T.-Y. Yang J.-Y. |
公開日期: | 2011 | 卷: | 27 | 期: | 7 | 起(迄)頁: | 745-749 | 來源出版物: | AIDS Research and Human Retroviruses | 摘要: | The objective of this study was to analyze recent infections and the molecular epidemiology of human immunodeficiency virus type 1 (HIV-1) among different risk groups since the outbreak of circulating recombinant form CRF07-BC among intravenous drug users (IDUs) in 2004 in Taiwan. Phylogenetic analysis was performed using the env and pol fragment sequences amplified from these specimens. The BED IgG capture incidence EIA (BED-CEIA assay) was used to determine recent infections. Among the 683 HIV-1-positive individuals enrolled between 2007 and 2009, 394 (57.7%) were subtype B, 260 (38.1%) were CRF07-BC, 26 (3.8%) were CRF01-AE, two (0.3%) were CRF08-BC, and one (0.1%) was CRF06-cpx. While the percentage of CRF07-BC decreased (58.5-17.9%, p<0.001) from 2007 to 2009, the percentage of subtype B increased (37.6% to 74.9%, p<0.001). A concordant decrease in the proportion of recent infections to new infections among IDUs (63.6% to 9.8%, p<0.001), accompanied with an increase of the proportion of recent infections in MSM (men having sex with men) (22.4-67.1%, p=0.77) and heterosexual groups (13.1-23.2%, p=0.852), was observed. The decrease in CRF07-BC infections and the reduction in the proportion of recent infections among IDUs reflected the success of harm reduction strategies initiated by the government in 2005. ? 2011, Mary Ann Liebert, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503547 | ISSN: | 0889-2229 | DOI: | 10.1089/aid.2010.0244 | SDG/關鍵字: | Pol protein; virus envelope protein; article; enzyme immunoassay; epidemic; gene sequence; government; heterosexuality; high risk behavior; high risk population; human; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; intravenous drug abuse; major clinical study; male; male homosexual; molecular epidemiology; nonhuman; nucleotide sequence; phylogeny; priority journal; Taiwan; unindexed sequence; vertical transmission; virus recombinant; virus transmission; virus typing; Adult; Cluster Analysis; Cross-Sectional Studies; Disease Outbreaks; env Gene Products, Human Immunodeficiency Virus; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Molecular Epidemiology; Molecular Sequence Data; Phylogeny; pol Gene Products, Human Immunodeficiency Virus; Risk-Taking; Sequence Analysis, DNA; Taiwan |
顯示於: | 醫學檢驗暨生物技術學系 |
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