https://scholars.lib.ntu.edu.tw/handle/123456789/503549
標題: | Molecular epidemiology of hepatitis d virus infection among injecting drug users with and without human immunodeficiency virus infection in Taiwan | 作者: | SUI-YUAN CHANG Yang C.-L. Ko W.-S. Liu W.-C. Lin C.-Y. Wu C.-H. Su Y.-C. Chang S.-F. Chen M.-Y. WANG-HUEI SHENG CHIEN-CHING HUNG SHAN-CHWEN CHANG |
公開日期: | 2011 | 卷: | 49 | 期: | 3 | 起(迄)頁: | 1083-1089 | 來源出版物: | Journal of Clinical Microbiology | 摘要: | An outbreak of human immunodeficiency virus (HIV) infection occurred among injecting drug users (IDU) in Taiwan between 2003 and 2006, when an extremely high prevalence of hepatitis C virus (HCV) infection was also detected. To determine whether clusters of hepatitis D virus (HDV) infection occurred in this outbreak, 4 groups of subjects were studied: group 1, HIV-infected IDU (n = 904); group 2, HIV-infected non-IDU (n = 880); group 3, HIV-uninfected IDU (n = 211); and group 4, HIV-uninfected non-IDU (n = 1,928). The seroprevalence of hepatitis B virus (HBV) was 19.8%, 18.4%, 17.1%, and 6.7%, and HDV seroprevalence among HBV carriers was 75.4%, 9.3%, 66.7%, and 2.3%, for groups 1, 2, 3, and 4, respectively. Ninety-nine of 151 (65.6%) HDV-seropositive IDU had HDV viremia: 5 were infected with HDV genotype I, 41 with genotype II, 51 with genotype IV, and 2 with genotypes II and IV. In the phylogenetic analysis, only one cluster of 4 strains within the HDV genotype II was identified. Among patients with HCV viremia, a unique cluster within genotype 1a was observed; yet, patients within this cluster did not overlap with those observed in the HDV phylogenetic analysis. In summary, although IDU had a significantly higher HDV seroprevalence, molecular epidemiologic investigations did not support that HDV was introduced at the same time as HCV among IDU. Copyright ? 2011, American Society for Microbiology. All Rights Reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503549 | ISSN: | 0095-1137 | DOI: | 10.1128/JCM.01154-10 | SDG/關鍵字: | adult; article; controlled study; delta agent hepatitis; drug abuse; female; genotype; Hepatitis B virus; hepatitis C; human; Human immunodeficiency virus infection; injecting drug user; major clinical study; male; molecular epidemiology; nucleotide sequence; phylogeny; priority journal; seroprevalence; Taiwan; viremia; virus carrier; virus strain; Adult; Aged; Cluster Analysis; Comorbidity; Disease Outbreaks; Drug Users; Female; Genotype; Hepatitis B; Hepatitis C; Hepatitis D; Hepatitis Delta Virus; HIV Infections; Humans; Male; Middle Aged; Molecular Epidemiology; Molecular Sequence Data; RNA, Viral; Sequence Analysis, DNA; Seroepidemiologic Studies; Substance Abuse, Intravenous; Taiwan; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human immunodeficiency virus |
顯示於: | 醫學檢驗暨生物技術學系 |
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