https://scholars.lib.ntu.edu.tw/handle/123456789/503651
標題: | Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate | 作者: | KAI-WEN HUANG Chen H.-H. Yang H.-C. Horng H.-E. Liao S.-H. Chieh J.-J. Yang Y. |
公開日期: | 2012 | 卷: | 7 | 期: | 6 | 起(迄)頁: | P06005 | 來源出版物: | Journal of Instrumentation | 摘要: | This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.? 2012 IOP Publishing Ltd and Sissa Medialab srl. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862992743&doi=10.1088%2f1748-0221%2f7%2f06%2fP06005&partnerID=40&md5=f5a8ea938e7db54b9d7d0426fd72d072 https://scholars.lib.ntu.edu.tw/handle/123456789/503651 |
ISSN: | 1748-0221 | DOI: | 10.1088/1748-0221/7/06/P06005 |
顯示於: | 醫學系 |
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