https://scholars.lib.ntu.edu.tw/handle/123456789/503668
標題: | Smoking and Hepatitis B Virus–Related Hepatocellular Carcinoma Risk: The Mediating Roles of Viral Load and Alanine Aminotransferase | 作者: | Wang Y.-H. YA-HUI CHUANG Wu C.-F. Jan M.-C. Wu W.-J. Lin C.-L. CHUN-JEN LIU YA-CHIEN YANG PEI-JER CHEN Lin S.-M. MONG-HSUN TSAI Huang Y.-W. MING-WHEI YU |
公開日期: | 2019 | 卷: | 69 | 期: | 4 | 起(迄)頁: | 1412-1425 | 來源出版物: | Hepatology | 摘要: | Smoking interacts with hepatitis B virus (HBV) to increase the risk of hepatocellular carcinoma (HCC), which might be explained by its role in antiviral immunity. We evaluated the potential mediating role of viral load and/or alanine aminotransferase (ALT) in the relation of smoking with HBV-associated HCC risk. Using multiple mediation analyses to analyze data from 209 HCC cases and 1,256 controls nested within a cohort of 4,841 male HBV carriers, we found that the effect of smoking on the risk of subsequent HCC was substantially mediated through viral load (percent mediated, 31.7%; P = 0.0054), and a significant mediation effect by both viral load and ALT was also evidenced. Among the 1,143 subjects with repeated measures of viral load and ALT over periods of up to 16 years, we further observed that a higher number of pack-years of smoking was associated with higher viral load, maintenance of a high viral load (>4.39 log copies/mL), more severe hepatotoxicity grade, and increased likelihood of ALT ?80 U/L (odds ratio, 3.14; 95% confidence interval, 1.03-9.64; odds ratio, 6.06; 95% confidence interval, 1.10-33.25, respectively, for 10-19 and ?20 pack-years versus nonsmokers) during follow-up. Furthermore, plasma interferon-γ levels were reduced in smokers compared with nonsmokers (interferon-γ-positive rate, 14.9% versus 28.7%; P < 0.0001) at baseline. Smoking was also associated with a reduced natural killer (NK) cell frequency in peripheral blood, characterized by reduced NK function through a systems immunology approach, after long-term follow-up in a subsample (n = 171). The combination of smoking and reduced NK cell frequency further increased viral load and the likelihood of ALT ?80 U/L. Conclusion: The data highlight a role of smoking in HBV viral load, underlining the importance of smoking prevention and cessation in hepatitis B management. ? 2018 by the American Association for the Study of Liver Diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503668 | ISSN: | 0270-9139 | DOI: | 10.1002/hep.30339 | SDG/關鍵字: | alanine aminotransferase; CD19 antigen; CD4 antigen; CD56 antigen; CD8alpha antigen; gamma interferon; hepatitis B surface antigen; hepatitis B(e) antigen; transcriptome; virus DNA; alanine aminotransferase; adult; Article; blood analysis; cancer risk; case control study; clinical evaluation; cohort analysis; controlled study; disease association; evidence based practice; female; follow up; hepatitis B; Hepatitis B virus; high risk population; human; immune response; immunology; liver cell carcinoma; liver toxicity; long term care; longitudinal study; major clinical study; male; natural killer cell; priority journal; protein blood level; risk assessment; risk factor; smoking; smoking cessation; smoking prevention; virus load; adverse event; blood; complication; hepatitis B; liver cell carcinoma; liver tumor; middle aged; smoking; virology; virus load; Adult; Alanine Transaminase; Carcinoma, Hepatocellular; Case-Control Studies; Cohort Studies; Hepatitis B; Humans; Killer Cells, Natural; Liver Neoplasms; Male; Middle Aged; Smoking; Viral Load |
顯示於: | 醫學檢驗暨生物技術學系 |
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