https://scholars.lib.ntu.edu.tw/handle/123456789/504776
標題: | Prenatal and perinatal risk factors and the clinical implications on autism spectrum disorder | 作者: | YI-LING CHIEN Chou M.-C. Chou W.-J. Wu Y.-Y. WEN-CHE TSAI YEN-NAN CHIU SUSAN SHUR-FEN GAU |
公開日期: | 2019 | 出版社: | SAGE Publications Ltd | 卷: | 23 | 期: | 3 | 起(迄)頁: | 783-791 | 來源出版物: | Autism | 摘要: | Prenatal and perinatal factors may increase the risk of autism spectrum disorder. However, little is known about whether unaffected siblings of probands with autism spectrum disorder also share the phenomenon and whether the prenatal/perinatal factors are related to the clinical severity of autistic symptoms. We compared the frequency of prenatal and perinatal factors among 323 probands with autism spectrum disorder (mean age ± standard deviation, 10.7 ± 3.5 years; males, 91.0%), 257 unaffected siblings (11.7 ± 4.5; 42.8%), and 1504 typically developing controls (8.9 ± 1.6 years; 53.1%); and investigated their effects on the severity of autistic symptoms. We found that probands with autism spectrum disorder and their unaffected siblings had more prenatal/perinatal events than typically developing controls with higher numbers of prenatal/perinatal factors in probands than in unaffected siblings. The prenatal/perinatal events were associated with greater stereotyped behaviors, social-emotional problems, socio-communication deficits, and overall severity. We also found that six prenatal/perinatal factors (i.e. preeclampsia, polyhydramnios, oligoamnios, placenta previa, umbilical cord knot, and gestational diabetes) were associated with the severity of autistic symptoms, particularly stereotyped behaviors and socio-communication deficits. Our findings suggest that prenatal and perinatal factors may potentially moderate the clinical expression of autism spectrum disorder. The underlying mechanism warrants further research. ? The Author(s) 2018. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049809744&doi=10.1177%2f1362361318772813&partnerID=40&md5=3a1e4e0f2e8d5bb467051530ab51478a https://scholars.lib.ntu.edu.tw/handle/123456789/504776 |
ISSN: | 1362-3613 | DOI: | 10.1177/1362361318772813 | SDG/關鍵字: | hemoglobin A1c; methylprednisolone; adult; Article; attention deficit disorder; autism; caregiver; cesarean section; child health; chromosome disorder; clinical trial; comparative study; controlled study; diabetes mellitus; distress syndrome; female; gestational age; head circumference; human; hydramnios; karyotype; major clinical study; male; perinatal period; phototherapy; preeclampsia; prematurity; prenatal period; priority journal; psychometry; questionnaire; reliability; resuscitation; risk factor; semi structured interview; social interaction; spontaneous abortion; stereotypy; umbilical cord; Wechsler intelligence scale for children; autism; causality; child; pregnancy; pregnancy complication; risk factor; severity of illness index; sibling; Taiwan; Autism Spectrum Disorder; Causality; Child; Female; Humans; Male; Pregnancy; Pregnancy Complications; Risk Factors; Severity of Illness Index; Siblings; Taiwan |
顯示於: | 臨床醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。