https://scholars.lib.ntu.edu.tw/handle/123456789/504927
標題: | Antidepressant-associated mania: Soon after switch from fluoxetine to mirtazapine in an elderly woman with mixed depressive features | 作者: | Liu C.C. Liang K.Y. Shih-Cheng Liao |
關鍵字: | Combined antidepressant therapy; Fluoxetine; Induced-mania; Mirtazapine; Mixed depressive states | 公開日期: | 2009 | 卷: | 23 | 期: | 2 | 起(迄)頁: | 220-222 | 來源出版物: | Journal of Psychopharmacology | 摘要: | Mirtazapine augmentation to a serotonin-reuptake inhibitor has been proposed to boost antidepressant effects and more likely to induce manic switch. Such a combined antidepressant therapy strategy should be used carefully if the patient's refractoriness is attributable to mixed depressive features. Mixed depression is more difficult to be treated by antidepressant monotherapy and related to higher risk of manic switch during treatment. We report a case with no previous history of bipolar disorder, whereas developed full-blown psychotic manic symptoms soon after switch from fluoxetine to mirtazapine. The patient's premorbid characters and clinical presentations suggested an implicit bipolarity that predisposed her to a manic switch. Her manic switch was likely to be triggered by a simulated combined effect because of complex drug interactions during shifting from fluoxetine to mirtazapine. For patients in mixed depressive states, mood stabilizers are preferable to antidepressants. ? 2009 British Association for Psychopharmacology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67651173276&doi=10.1177%2f0269881108089807&partnerID=40&md5=1910c4f4c7fe5ba3cbb3d52a150940f5 https://scholars.lib.ntu.edu.tw/handle/123456789/504927 |
ISSN: | 0269-8811 | DOI: | 10.1177/0269881108089807 | SDG/關鍵字: | fluoxetine; mirtazapine; alpha adrenergic receptor blocking agent; drug derivative; fluoxetine; mianserin; mirtazapine; serotonin uptake inhibitor; aged; article; bipolar disorder; case report; disease predisposition; drug choice; drug effect; drug substitution; drug withdrawal; female; grandiose delusion; human; major depression; manic psychosis; priority journal; symptom; bipolar disorder; chemically induced disorder; dose response; drug administration; drug interaction; major depression; psychological aspect; Adrenergic alpha-Antagonists; Aged; Bipolar Disorder; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Fluoxetine; Humans; Mianserin; Serotonin Uptake Inhibitors |
顯示於: | 醫學系 |
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