https://scholars.lib.ntu.edu.tw/handle/123456789/504940
標題: | Comparative analysis between psychological and endoscopic profiles in patients with gastroesophageal reflux disease: A prospective study based on screening endoscopy | 作者: | YI-CHIA LEE HSIU-PO WANG HAN-MO CHIU Shih-Cheng Liao Huang S.-P. YO-PING LAI MING-SHIANG WU MING-FONG CHEN Lin J.-T. |
公開日期: | 2006 | 出版社: | Blackwell Publishing | 卷: | 21 | 期: | 5 | 起(迄)頁: | 798-804 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background: Associations between psychological and endoscopic profiles are not clearly validated among the heterogeneous patients with gastroesophageal reflux disease (GERD). The purpose of the present paper was therefore to identify any associations by means of cross-sectional study. Methods: Consecutive participants in a health screening program were enrolled. Definition and severity of erosive esophagitis were assessed with Los Angeles classification. Frequency and severity of psychological symptoms were measured with a 30-item Brief Symptom Rating Scale (BSRS) and personality traits with a short form of the Maudsley Personality Inventory (MPI). Statistic analyses were performed based on the presence of GERD symptoms or endoscopic esophagitis. Results: A total of 4600 participants were recruited. There were 1331 subjects (29%) with manifestations suggesting GERD, including non-erosive reflux disease (NERD) in 488 (10.6%), symptomatic erosive esophagitis (SEE) in 164 (3.6%), and asymptomatic erosive esophagitis (AEE) in 679 (14.8%). The BSRS parameters were significantly higher in symptomatic subjects (i.e. NERD and SEE subjects; P < 0.001); neuroticism scores were also higher (P < 0.001), but extroversion scores (P < 0.001) were lower than those of asymptomatic subjects. Following logistic regression analysis, independent risk factors for GERD symptoms were female gender (odds ratio [OR]: 1.596; 95% confidence interval [CI]: 1.303-1.955) and higher neuroticism scores (OR: 1.046; 95%CI: 1.032-1.06). For erosive esophagitis, independent risk factors were male gender (OR: 2.943; 95%CI: 2.359-3.671) and higher body mass index scores (OR: 1.098; 95%CI: 1.069-1.127). Conclusions: Psychological characteristics predict likelihood of GERD symptoms but not structural state of esophagus. Male gender and obesity are risk factors for erosive esophagitis; whereas female gender and neuroticism are more likely to be associated with GERD symptoms. ? 2005 Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646898867&doi=10.1111%2fj.1440-1746.2005.04034.x&partnerID=40&md5=08935b5150a19b6b31c78b6247eb74a9 https://scholars.lib.ntu.edu.tw/handle/123456789/504940 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2005.04034.x | SDG/關鍵字: | adult; article; body mass; Brief Symptom Rating Scale; comparative study; controlled study; disease association; disease severity; extraversion; female; gastroesophageal reflux; gastrointestinal endoscopy; gender; human; major clinical study; male; maudsley personality inventory; neurosis; personality; priority journal; prospective study; psychological aspect; rating scale; reflux esophagitis; risk factor; screening |
顯示於: | 醫學系 |
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