https://scholars.lib.ntu.edu.tw/handle/123456789/505147
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | Chen T.-C. | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | HURNG-YI WANG | en_US |
dc.contributor.author | TAI-CHUNG TSENG | en_US |
dc.contributor.author | Cheng H.-R. | en_US |
dc.contributor.author | CHEN-HUA LIU | en_US |
dc.contributor.author | DING-SHINN CHEN | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.creator | Liu C.-J.;Chen T.-C.;Chen P.-J.;Hurng-Yi Wang;Tseng T.-C.;Cheng H.-R.;Liu C.-H.;Chen D.-S.;Kao J.-H. | - |
dc.date.accessioned | 2020-06-26T07:52:30Z | - |
dc.date.available | 2020-06-26T07:52:30Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919655097&doi=10.1111%2fjgh.12654&partnerID=40&md5=236fc47bb8dc718b4670e0b282876131 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/505147 | - |
dc.description.abstract | Background and Aim: Patients with hepatitis B virus (HBV) genotype B infection experience hepatitis B e-antigen (HBeAg) seroconversion at an earlier stage than do patients with genotype C infection. Therefore, this study investigated whether the differential phenotypes are related to HBV genomic evolution. Methods: Thirty-three HBeAg-positive patients with a mean follow-up of 3.1 years were enrolled: 16 at the immune tolerance stage (group I) and 17 at the immune clearance stage (group II). The evolution rates of paired viral genomes at enrollment and at the final follow-up in the full-length genome (μf), nonoverlapping regions (synonymous [μs] and nonsynonymous [μa]), and overlapping regions (μ) were calculated. The evolution rates were then compared according to serum alanine aminotransferase (ALT) levels and HBV genotype. Results: The overall μf evolution rate was lower in group I than in group II (1.4×10-5±3.3×10-5 vs 1.2×10-3±1.2×10-3 nucleotide substitution/site/year, P<0.001). We observed similar results for the μs, μa, and μ evolution rates. All evolution parameters were comparable between genotypes B and C. We determined a positive correlation between μa/y and the area under the average ALT time curve in genotype B (R2=0.6935, P<0.0001), but not in genotype C (R2=0.1606, P=0.124). Conclusion: The evolution rate of the HBV genome is higher at the immune clearance stage than at the immune tolerance stage. Host immune selection might play a role in triggering evolution of genotype B. ? 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. | en_US |
dc.publisher | Blackwell Publishing | en_US |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology (Australia) | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; hepatitis B(e) antigen; nucleotide; alanine aminotransferase; hepatitis B(e) antigen; adult; alanine aminotransferase blood level; Article; clinical article; controlled study; evolution; female; hepatitis B; Hepatitis B virus genotype B; Hepatitis B virus genotype C; hepatitis C; human; immune clearance; immune status; immunity; immunological tolerance; male; nonhuman; phenotype; priority journal; virus genome; blood; follow up; genetics; genotype; hepatitis B; Hepatitis B virus; heterozygote; immunology; molecular evolution; time; virology; virus genome; young adult; Adult; Alanine Transaminase; Carrier State; Evolution, Molecular; Female; Follow-Up Studies; Genome, Viral; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Male; Time Factors; Young Adult | - |
dc.title | Micro-evolution of the hepatitis B virus genome in hepatitis B e-antigen-positive carriers: Comparison of genotypes B and C at various immune stages | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/jgh.12654 | - |
dc.identifier.pmid | 25040688 | - |
dc.identifier.scopus | 2-s2.0-84919655097 | - |
dc.relation.pages | 172-177 | en_US |
dc.relation.journalvolume | 30 | en_US |
dc.relation.journalissue | 1 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Ecology and Evolutionary Biology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Research | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0003-1708-8734 | - |
crisitem.author.orcid | 0000-0003-3622-9707 | - |
crisitem.author.orcid | 0000-0001-7791-6154 | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 免疫學研究所 |
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