https://scholars.lib.ntu.edu.tw/handle/123456789/506077
標題: | Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders | 作者: | Chen, P. Huang, N.-T. Chung, M.-T. Cornell, T.T. Kurabayashi, K. NIEN-TSU HUANG |
關鍵字: | Anti-cytokine drug delivery; Field effect transistor nanowire; Label-free biosensors; Microcantilever; Microfluidics; Optical resonator; Personalized medicine; Pro-inflammatory cytokine; Surface plasmon resonance | 公開日期: | 2015 | 卷: | 95 | 起(迄)頁: | 90-103 | 來源出版物: | Advanced Drug Delivery Reviews | 摘要: | Systemic inflammatory disorders resulting from infection, trauma, surgery, and severe disease conditions pose serious threats to human health leading to organ dysfunction, organ failure, and mortality. The highly complex and dynamic nature of the immune system experiencing acute inflammation makes immunomodulatory therapy blocking pro-inflammatory cytokines very challenging. Successful therapy requires the ability to determine appropriate anti-cytokine drugs to be delivered at a right dose in a timely manner. Label-free micro- and nano-biosensors hold the potential to overcome the current challenges, enabling cytokine-targeted treatments to be tailored according to the immune status of an individual host with their unique cytokine biomarker detection capabilities. This review studies the recent progress in label-free cytokine biosensors, summarizes their performances and potential merits, and discusses future directions for their advancements to meet challenges towards personalized anti-cytokine drug delivery. ? 2015 Elsevier B.V. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/506077 | DOI: | 10.1016/j.addr.2015.09.005 | SDG/關鍵字: | Biosensors; Drug dosage; Field effect transistors; Health risks; Microfluidics; Optical resonators; Surface plasmon resonance; Targeted drug delivery; Cytokine biosensors; Cytokines; Detection capability; Inflammatory disorders; Label-free biosensor; Micro-cantilevers; Personalized medicines; Pro-inflammatory cytokines; Controlled drug delivery; aptamer; cytokine; gamma interferon; gold nanorod; interleukin 2; interleukin 4; interleukin 5; interleukin 8; nanowire; tumor necrosis factor alpha; cytokine; amperometric biosensor; Article; biosensor; cytokine release; electrochemical detection; electrochemical impedance spectroscopy; fiber optics; field effect transistor; human; immunoassay; immunomodulation; inflammatory disease; limit of detection; microfluidics; microtechnology; nanosensor; nonhuman; optical biosensor; personalized medicine; priority journal; quartz crystal microbalance; surface plasmon resonance; systemic disease; systemic inflammatory disease; genetic procedures; immunology; inflammation; nanomedicine; personalized medicine; Biosensing Techniques; Cytokines; Humans; Immunoassay; Inflammation; Microfluidics; Nanomedicine; Precision Medicine |
顯示於: | 電機工程學系 |
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