https://scholars.lib.ntu.edu.tw/handle/123456789/506321
Title: | Whole pelvic helical tomotherapy for locally advanced cervical cancer: Technical implementation of IMRT with helical tomothearapy | Authors: | Hsieh C.-H. Wei M.-C. Lee H.-Y. Hsiao S.-M. Chen C.-A. LI-YING WANG Hsieh Y.-P. Tsai T.-H. Chen Y.-J. Shueng P.-W. |
Issue Date: | 2009 | Journal Volume: | 4 | Journal Issue: | 1 | Start page/Pages: | 62 | Source: | Radiation Oncology | Abstract: | Background: To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer. Methods: Between November 1st, 2006 and May 31, 2009, 10 cervical cancer patients histologically confirmed were enrolled. All of the patients received definitive concurrent chemoradiation (CCRT) with whole pelvic HT (WPHT) followed by brachytherapy. During WPHT, all patients were treated with cisplatin, 40 mg/m2intravenously weekly. Toxicity of treatment was scored according to the Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0). Results: The mean survival was 25 months (range, 3 to 27 months). The actuarial overall survival, disease-free survival, locoregional control and distant metastasis-free rates at 2 years were 67%, 77%, 90% and 88%, respectively. The average of uniformity index and conformal index was 1.06 and 1.19, respectively. One grade 3 of acute toxicity for diarrhea, thrombocytopenia and three grade 3 leucopenia were noted during CCRT. Only one grade 3 of subacute toxicity for thrombocytopenia was noted. There were no grade 3 or 4 subacute toxicities of anemia, leucopenia, genitourinary or gastrointestinal effects. Compared with conventional whole pelvic radiation therapy (WPRT), WPHT decreases the mean dose to rectum, bladder and intestines successfully. Conclusion: HT provides feasible clinical outcomes in locally advanced cervical cancer patients. Long-term follow-up and enroll more locally advanced cervical carcinoma patients by limiting bone marrow radiation dose with WPHT technique is warranted. ? 2009 Hsieh et al; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-74049106606&doi=10.1186%2f1748-717X-4-62&partnerID=40&md5=361d5801e202d9c18e397671e65abf34 https://scholars.lib.ntu.edu.tw/handle/123456789/506321 |
ISSN: | 1748-717X | DOI: | 10.1186/1748-717X-4-62 | SDG/Keyword: | cisplatin; antineoplastic agent; cisplatin; adult; advanced cancer; aged; anemia; article; brachytherapy; cancer control; cancer radiotherapy; cancer survival; clinical article; controlled study; diarrhea; disease free survival; external beam radiotherapy; female; gastrointestinal toxicity; human; intensity modulated radiation therapy; leukopenia; overall survival; radiation dose; thrombocytopenia; tomotherapy; treatment outcome; treatment planning; urogenital tract disease; uterine cervix cancer; cancer staging; intensity modulated radiation therapy; Kaplan Meier method; methodology; middle aged; mortality; multimodality cancer therapy; retrospective study; spiral computer assisted tomography; uterine cervix tumor; Adult; Aged; Antineoplastic Agents; Brachytherapy; Cisplatin; Combined Modality Therapy; Female; Humans; Kaplan-Meiers Estimate; Middle Aged; Neoplasm Staging; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Retrospective Studies; Tomography, Spiral Computed; Uterine Cervical Neoplasms |
Appears in Collections: | 物理治療學系所 |
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