https://scholars.lib.ntu.edu.tw/handle/123456789/506621
標題: | Effects and mechanism of the HECT study (hybrid exercise-cognitive trainings) in mild ischemic stroke with cognitive decline: fMRI for brain plasticity, biomarker and behavioral analysis | 作者: | Yeh T.-T. Chang K.-C. Wu C.-Y. YA-YUN LEE Chen P.-Y. Hung J.-W. |
公開日期: | 2018 | 出版社: | Elsevier Inc | 卷: | 9 | 起(迄)頁: | 164-171 | 來源出版物: | Contemporary Clinical Trials Communications | 摘要: | Purpose: Cognitive decline after stroke is highly associated with functional disability. Empirical evidence shows that exercise combined cognitive training may induce neuroplastic changes that modulate cognitive function. However, it is unclear whether hybridized exercise-cognitive training can facilitate cortical activity and physiological outcome measures and further influence on the cognitive function after stroke. This study will investigate the effects of two hybridized exercise-cognitive trainings on brain plasticity, physiological biomarkers and behavioral outcomes in stroke survivors with cognitive decline. Methods and significance: This study is a single-blind randomized controlled trial. A target sample size of 75 participants is needed to obtain a statistical power of 95% with a significance level of 5%. Stroke survivors with mild cognitive decline will be stratified by Mini-Mental State Examination scores and then randomized 1:1:1 to sequential exercise-cognitive training, dual-task exercise-cognitive training or control groups. All groups will undergo training 60 min/day, 3 days/week, for a total of 12 weeks. The primary outcome is the resting-state functional connectivity and neural activation in the frontal, parietal and occipital lobes in functional magnetic resonance imaging. Secondary outcomes include physiological biomarkers, cognitive functions, physical function, daily functions and quality of life. This study may differentiate the effects of two hybridized trainings on cognitive function and health-related conditions and detect appropriate neurological and physiological indices to predict training effects. This study capitalizes on the groundwork for a non-pharmacological intervention of cognitive decline after stroke. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042371322&doi=10.1016%2fj.conctc.2018.02.003&partnerID=40&md5=df0d061f4742742bddecf7da888827c5 https://scholars.lib.ntu.edu.tw/handle/123456789/506621 |
ISSN: | 2451-8654 | DOI: | 10.1016/j.conctc.2018.02.003 | SDG/關鍵字: | biological marker; cholesterol; hemoglobin A1c; adult; aged; Article; brain ischemia; cognition; cognitive therapy; controlled study; female; frontal lobe; functional connectivity; functional magnetic resonance imaging; human; hybrid exercise cognitive training; intervention study; major clinical study; male; mild cognitive impairment; Mini Mental State Examination; nerve cell plasticity; occipital lobe; parietal lobe; priority journal; quality of life; randomized controlled trial; survivor; treatment outcome |
顯示於: | 物理治療學系所 |
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