https://scholars.lib.ntu.edu.tw/handle/123456789/507617
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin P.-Y. | en_US |
dc.contributor.author | Jen H.-Y. | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.contributor.author | Sheu F. | en_US |
dc.contributor.author | YA-HUI CHUANG | en_US |
dc.creator | Lin P.-Y.;Jen H.-Y.;Chiang B.-L.;Sheu F.;Ya-Hui Chuang | - |
dc.date.accessioned | 2020-07-01T06:54:59Z | - |
dc.date.available | 2020-07-01T06:54:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0019-2805 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/507617 | - |
dc.description.abstract | Summary: T helper type 2 (Th2) cells, which produce interleukin-4 (IL-4), IL-5 and IL-13, control immunity to all forms of allergic inflammatory responses. Interleukin-21 (IL-21) reduces allergic symptoms in murine models and inhibits IL-4-induced IgE secretion by B cells. However, whether or not IL-21 directly affects Th2 cells, which leads to reduced allergic symptoms, is unclear. In this study, we investigated the effects of IL-21 on the differentiation and effector functions of Th2 cells. We found that IL-21 reduced the number of differentiated Th2 cells and these Th2 cells showed a diminished Th2 cytokine production. Interleukin-21 suppressed Th2 cytokine production of already polarized Th2 cells by down-regulation of transcription factor GATA-3. It also induced apoptosis of Th2 cells with decreased anti-apoptotic factor Bcl-2. Intranasal administration of IL-21 at the beginning of ovalbumin (OVA) sensitization or before OVA challenge decreased Th2 cytokines in the bronchoalveolar lavage fluid of OVA/alum-immunized allergic mice. In addition, the inhibitory effects of IL-21 on Th2 effector functions can also be found in allergic patients. Our results demonstrate that IL-21 suppresses the development of Th2 cells and functions of polarized Th2 cells. Hence, the administration of IL-21 may be considered for use as a preventive and therapeutic approach when dealing with Th2-mediated allergic diseases. ? 2014 John Wiley & Sons Ltd. | - |
dc.relation.ispartof | Immunology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | gamma interferon; immunoglobulin E; interleukin 13; interleukin 17; interleukin 21 receptor; interleukin 4; interleukin 5; protein bcl 2; recombinant interleukin 21; retinoid related orphan receptor gamma; transcription factor GATA 3; transcription factor T bet; antiallergic agent; GATA3 protein, human; Gata3 protein, mouse; interleukin 21; interleukin derivative; ovalbumin; protein bcl 2; recombinant protein; transcription factor GATA 3; allergic rhinitis; animal experiment; animal model; antibody production; apoptosis; Article; B lymphocyte; CD4+ T lymphocyte; controlled study; cytokine production; effector cell; female; human; human cell; lung lavage; lymphocyte differentiation; mouse; nonhuman; peripheral blood mononuclear cell; priority journal; Th2 cell; animal; Bagg albino mouse; biosynthesis; case control study; cell culture; cell differentiation; disease model; drug effects; genetics; immunology; metabolism; pathology; phenotype; Respiratory Hypersensitivity; T lymphocyte receptor gene; Th2 cell; transgenic mouse; Animals; Anti-Allergic Agents; Apoptosis; Case-Control Studies; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Female; GATA3 Transcription Factor; Genes, T-Cell Receptor; Humans; Interleukins; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin; Phenotype; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Respiratory Hypersensitivity; Rhinitis, Allergic; Th2 Cells | - |
dc.title | Interleukin-21 suppresses the differentiation and functions of T helper 2 cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/imm.12419 | - |
dc.identifier.pmid | 25351608 | - |
dc.identifier.scopus | 2-s2.0-84924390112 | - |
dc.relation.pages | 668-676 | - |
dc.relation.journalvolume | 144 | - |
dc.relation.journalissue | 4 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.orcid | 0000-0003-0857-0035 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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