https://scholars.lib.ntu.edu.tw/handle/123456789/507625
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin S.-C. | en_US |
dc.contributor.author | YA-HUI CHUANG | en_US |
dc.contributor.author | YAO-HSU YANG | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.creator | Lin S.-C. ;Ya-Hui Chuang ;Yang Y.-H. ;Chiang B.-L. | - |
dc.date.accessioned | 2020-07-01T06:55:01Z | - |
dc.date.available | 2020-07-01T06:55:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0905-6157 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/507625 | - |
dc.description.abstract | Background: Atopic dermatitis (AD) is a kind of eczema with an inflammatory, relapsing, non-contagious, and pruritic skin disorder. It is associated with the local infiltration of T helper type 2 (Th2) cells that secrete interleukin (IL)-4 and IL-5. IL-21 is a member of IL-2 family cytokine mainly expressed by activated CD4+ T lymphocytes. Until now, there is no clinical research in the expression of IL-21 in patients with AD. Methods: We analyzed serum levels of total immunoglobulin E (IgE), allergen-specific IgE, and cytokines IL-4, IL-5, IFN-γ, IL-17, and IL-21 in AD cases and controls. In addition, cytokine levels in the culture supernatants of peripheral blood mononuclear cells stimulated with anti-CD3 and anti-CD28 Abs, phytohemagglutin (PHA), or pokeweed mitogen (PWM) were measured. We also assessed clinical skin severity by Scoring of Atopic Dermatitis (SCORAD) index. Results: Our results showed that serum total IgE in the case group was significantly higher than that of control group (365.449±52.945 and 39.243±7.605IU/ml, respectively). Logistic regression analysis system reveals serum levels of IL-21 and IFN-γ are significantly correlated. However, IL-21 and IL-4, IL-21 and IL-5, as well as IL-21 and IL-17 showed no correlation. Conclusion: A significantly decreased level of IL-21 was observed in children suffering with severe AD compared with controls, suggesting that IL-21 may play a role in AD. ? 2011 John Wiley & Sons A/S. | - |
dc.relation.ispartof | Pediatric Allergy and Immunology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD28 antigen; CD3 antigen; CD4 antigen; gamma interferon; immunoglobulin E; interleukin 17; interleukin 21; interleukin 4; interleukin 5; phytohemagglutinin; pokeweed mitogen; article; atopic dermatitis; CD4+ T lymphocyte; child; clinical article; controlled study; cytokine release; disease severity; female; human; immunoglobulin blood level; male; peripheral blood mononuclear cell; priority journal; Scoring of Atopic Dermatitis index; scoring system; supernatant; T lymphocyte activation; Th2 cell; Antibodies, Monoclonal; Antigens, CD28; Antigens, CD3; Cells, Cultured; Child; Child, Preschool; Dermatitis, Atopic; Disease Progression; Down-Regulation; Female; Humans; Immunoglobulin E; Interferon-gamma; Interleukins; Male; Phytohemagglutinins; Pokeweed Mitogens; Th2 Cells | - |
dc.title | Decrease in interleukin-21 in children suffering with severe atopic dermatitis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1399-3038.2011.01209.x | - |
dc.identifier.pmid | 22122790 | - |
dc.identifier.scopus | 2-s2.0-82455166914 | - |
dc.relation.pages | 869-875 | - |
dc.relation.journalvolume | 22 | - |
dc.relation.journalissue | 8 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0003-0857-0035 | - |
crisitem.author.orcid | 0000-0002-6266-9864 | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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