|Title:||MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia||Authors:||Ko Y.-C.
|Issue Date:||2014||Journal Volume:||38||Journal Issue:||5||Start page/Pages:||625-631||Source:||Leukemia Research||Abstract:||
Let-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer. We evaluated the significance of let-7a-3 gene methylation in patients with de novo acute myeloid leukemia (AML). Let-7a-3 was methylated in 81.1% (73/90), partially methylated in 12.2% (11/90), or unmethylated in 6.7% (6/90) of patients. Let-7a-3 methylation correlated with AML karyotyping and CCAAT/enhancer binding protein α (CEBPA) methylation. Kaplan-Meier survival analysis predicted that let-7a-3 hypermethylation correlated with better survival in AML with hypomethylated CEBPA or with hypomethylated CEBPA without the favorable karyotype. We conclude that let-7a-3 methylation is a positive prognosticator for AML patients with hypomethylated CEBPA. ? 2014 Elsevier Ltd.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/507683||ISSN:||0145-2126||DOI:||10.1016/j.leukres.2014.03.008||metadata.dc.subject.other:||Acute myeloid leukemia; CCAAT/enhancer binding protein α; DNA methylation; miRNA let-7a-3; Adolescent; Adult; Aged; Aged, 80 and over; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; DNA Methylation; Humans; Karyotyping; Leukemia, Myeloid, Acute; MicroRNAs; Middle Aged; Promoter Regions, Genetic
|Appears in Collections:||醫學檢驗暨生物技術學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.