https://scholars.lib.ntu.edu.tw/handle/123456789/507693
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Li C.-H. | en_US |
dc.contributor.author | Chen P.-Y. | en_US |
dc.contributor.author | Chang U.-M. | en_US |
dc.contributor.author | Kan L.-S. | en_US |
dc.contributor.author | WOEI-HORNG FANG | en_US |
dc.contributor.author | KEH-SUNG TSAI | en_US |
dc.contributor.author | Lin S.-B. | en_US |
dc.creator | Li C.-H.;Chen P.-Y.;Chang U.-M.;Kan L.-S.;Woei-Horng Fang;Tsai K.-S.;Lin S.-B. | - |
dc.date.accessioned | 2020-07-01T07:39:41Z | - |
dc.date.available | 2020-07-01T07:39:41Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/507693 | - |
dc.description.abstract | Lanostanoid triterpenes isolated from Ganoderma amboinense were found to inhibit the growth of numerous cancer cell lines, and some of them inhibited the activities of topoisomerases I and IIα in vitro. Among the bioactive isolates, one of the most potent triterpene was identified to be 3α-hydroxy-15α-acetoxy-lanosta-7,9(11),24-trien-26-oic acid, ganoderic acid X (GAX). Treatment of human hepatoma HuH-7 cells with GAX caused immediate inhibition of DNA synthesis as well as activation of ERK and JNK mitogen-activated protein kinases, and cell apoptosis. Molecular events of apoptosis including degradation of chromosomal DNA, decrease in the level of Bcl-xL, the disruption of mitochondrial membrane, cytosolic release of cytochrome c and activation of caspase-3 were elucidated. The ability of GAX to inhibit topoisomerases and to sensitize the cancer cells toward apoptosis fulfills the feature of a potential anticancer drug. ? 2005 Elsevier Inc. All rights reserved. | - |
dc.relation.ispartof | Life Sciences | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 3alpha hydroxy 15alpha acetoxylanosta 7,9(11),24 trien 26 oic acid; caspase 3; cytochrome c; DNA topoisomerase; DNA topoisomerase (ATP hydrolysing); ganoderma amboinense extract; mitogen activated protein kinase; plant extract; protein bcl xl; stress activated protein kinase; topoisomerase IIalpha; triterpene; unclassified drug; apoptosis; article; cancer cell culture; cancer inhibition; chromosome; controlled study; cytosol; DNA degradation; DNA synthesis inhibition; drug identification; drug isolation; drug potency; drug sensitization; enzyme activation; enzyme activity; enzyme inhibition; enzyme release; Ganoderma; ganoderma amboinense; hepatoma cell; human; human cell; medicinal plant; membrane damage; mitochondrial membrane; molecule; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II, Eukaryotic; DNA-Binding Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Ganoderma; Humans; JNK Mitogen-Activated Protein Kinases; Lanosterol; Medicine, Chinese Traditional; Molecular Structure; Neoplasms; Triterpenes; Ganoderma | - |
dc.title | Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.lfs.2004.09.045 | - |
dc.identifier.pmid | 15878354 | - |
dc.identifier.scopus | 2-s2.0-18844383202 | - |
dc.relation.pages | 252-265 | - |
dc.relation.journalvolume | 77 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4728-5931 | - |
crisitem.author.orcid | 0000-0001-8528-1566 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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