https://scholars.lib.ntu.edu.tw/handle/123456789/507854
標題: | The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes | 作者: | Chang Y.-S. CHI-NIEN CHEN SUH-FANG JENG Su Y.-N. CHIEN-YI CHEN HUNG-CHIEH CHOU PO-NIEN TSAO Hsieh W.-S. |
公開日期: | 2017 | 出版社: | Elsevier (Singapore) Pte Ltd | 卷: | 58 | 期: | 6 | 起(迄)頁: | 529-533 | 來源出版物: | Pediatrics and Neonatology | 摘要: | Background Soluble fms-like tyrosine kinase receptor-1 (sFlt-1)/placental growth factor (PlGF) ratio has been studied extensively as a predictive marker for pre-eclampsia. However, its usefulness for predicting neonatal outcomes remains unknown. This study aimed to evaluate the association of sFlt-1/PlGF ratio with pregnancy outcomes, neonatal morbidities and short-term postnatal growth patterns in pregnant women and their babies. Methods sFlt-1 and PlGF were measured in women with fetal intrauterine growth retardation (IUGR) or pre-eclampsia during gestational age (GA) of 16–36 weeks. These women were classified into high- and low-ratio groups with a sFlt-1/PlGF cut-off ratio of 85. The maternal and neonatal outcomes were retrospectively reviewed and compared between the two groups. Results A total of 25 pregnant women were recruited. Thirteen of them had a sFlt-1/PlGF ratio over 85 and twelve had a ratio of less than 85. The median duration from elevation of sFlt-1/PlGF to delivery was 4.5 weeks. Women in the high SFlt-1/PlGF ratio group had higher rates of intrauterine fetal demise (2/13 vs. 0/12) and early termination (1/13 vs. 0/12). The surviving offspring in this group had a higher incidence of preterm birth (GA: 31.4 ± 2.9 weeks vs. 37.3 ± 1.3 weeks, p < 0.001), lower birth weight (1142 ± 472 g vs. 2311 ± 236 g, p < 0.001), higher incidence of respiratory distress syndrome (6/10 vs. 0/12, p = 0.002) and bronchopulmonary dysplasia (4/10 vs. 0/12, p = 0.01). However, the percentile of body weight, height and head circumference at 28 days of age, 56 days of age and the corrected age of 6 months were comparable between groups. Conclusions High sFlt-1/PlGF ratio in pregnant women is associated with poor pregnancy and neonatal outcomes. Therefore, the monitoring of sFlt-1/PlGF ratio in pregnant women with fetal IUGR and timely management for placenta-associated diseases are recommended. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019695343&doi=10.1016%2fj.pedneo.2016.10.005&partnerID=40&md5=6ba40f3e0beba561ff4a8656b8c06f4c https://scholars.lib.ntu.edu.tw/handle/123456789/507854 |
ISSN: | 1875-9572 | DOI: | 10.1016/j.pedneo.2016.10.005 | SDG/關鍵字: | acetylsalicylic acid; magnesium sulfate; placental growth factor; sildenafil; soluble fms like tyrosine kinase receptor 1; unclassified drug; vasculotropin receptor 1; FLT1 protein, human; PGF protein, human; placental growth factor; vasculotropin receptor 1; adult; Article; birth weight; body height; body weight; clinical article; disease association; female; fetus; gestational age; head circumference; human; incidence; intrauterine growth retardation; lung dysplasia; newborn; newborn morbidity; outcome assessment; postnatal growth; predictive value; preeclampsia; pregnancy outcome; pregnancy termination; premature labor; respiratory distress syndrome; retrospective study; blood; lung dysplasia; pregnancy; Adult; Bronchopulmonary Dysplasia; Female; Fetal Growth Retardation; Humans; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Retrospective Studies; Vascular Endothelial Growth Factor Receptor-1 |
顯示於: | 物理治療學系所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。