|Title:||Clonality of fluconazole-nonsusceptible Candida tropicalis in bloodstream infections, Taiwan, 2011-2017||Authors:||YU-CHUNG CHUANG
Lo, Hsiu Jung
|Issue Date:||1-Jan-2019||Publisher:||CENTERS DISEASE CONTROL & PREVENTION||Journal Volume:||25||Journal Issue:||9||Start page/Pages:||1668||Source:||Emerging Infectious Diseases||Abstract:||
© 2019 Centers for Disease Control and Prevention (CDC). All rights reserved. Candida tropicalis is the leading cause of non-C. albicans candidemia in tropical Asia and Latin America. We evaluated isolates from 344 patients with an initial episode of C. tropicalis candidemia. We found that 58 (16.9%) patients were infected by fluconazole-nonsusceptible (FNS) C. tropicalis with cross resistance to itraconazole, voriconazole, and posaconazole; 55.2% (32/58) of patients were azole-naive. Multilocus sequence typing analysis revealed FNS isolates were genetically closely related, but we did not see time- or place-clustering. Among the diploid sequence types (DSTs), we noted DST225, which has been reported from fruit in Taiwan and hospitals in Beijing, China, as well as DST376 and DST505-7, which also were reported from hospitals in Shanghai, China. Our findings suggest cross-boundary expansion of FNS C. tropicalis and highlight the importance of active surveillance of clinical isolates to detect dissemination of this pathogen and explore potential sources in the community.
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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