https://scholars.lib.ntu.edu.tw/handle/123456789/508011
標題: | An Outbreak of Coxsackievirus A16 Infection: Comparison With Other Enteroviruses in a Preschool in Taipei | 作者: | Wu P.-C. LI-MIN HUANG CHUAN-LIANG KAO Fan T.-Y. Cheng A.-L. LUAN-YIN CHANG |
公開日期: | 2010 | 卷: | 43 | 期: | 4 | 起(迄)頁: | 271-277 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/Purpose: The transmission rate of enteroviruses in young children remains unclear. Therefore, we carried out active surveillance in preschool children to investigate the transmission rate and clinical manifestation of enteroviruses. Methods: From September 2006 to December 2008, we monitored infectious diseases in children 2(-3 years of age) in a preschool in Taipei. If any child had a febrile illness or symptoms/signs of enteroviral infection [e.g. herpangina or hand-foot-and-mouth disease (HFMD)], we performed viral isolation and enterovirus polymerase chain reaction. VP1 sequencing was performed to define their serotypes. We also collected clinical data and analyzed transmission rates. Results: There were eight episodes of enterovirus infection during the study period. The serotypes included coxsackievirus A4 (CA4), CA2 and CA16. The transmission rates of CA4 and CA2 among children in same class were 26% and 35%, respectively. Between November 28 and December 12, 2008, 13/21 (61.9%) children contracted herpangina and/or HFMD. The average age was 2.82 (range, 2.43-3.39) years. CA16 was detected in 10/13 (76.9%) of the throat swabs by polymerase chain reaction VP1 genotyping. Compared with previous CA2 and CA4 outbreaks, CA16 had a significantly higher transmission rate (p = 0.035) and resulted in more cases of HFMD (p < 0.001). The transmission duration of coxsackie A viruses within the same class ranged from 12 to 40 days. Conclusion: Compared with CA2 and CA4, CA16 infections resulted in more cases of HFMD and had significantly higher transmission rates in preschoolers. ? 2010 Taiwan Society of Microbiology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/508011 | ISSN: | 1684-1182 | DOI: | 10.1016/S1684-1182(10)60043-6 | SDG/關鍵字: | protein VP1; virus DNA; virus RNA; capsid protein; virus RNA; animal cell; article; child; childhood disease; comparative study; Coxsackie virus A; Coxsackie virus infection; disease surveillance; epidemic; female; genotype; hand foot and mouth disease; herpangina; human; human cell; major clinical study; male; nonhuman; preschool child; real time polymerase chain reaction; reverse transcription polymerase chain reaction; serotype; Taiwan; throat culture; virus culture; virus isolation; virus transmission; classification; Coxsackievirus Infections; DNA sequence; Enterovirus; genetics; Hand, Foot and Mouth Disease; herpangina; incidence; isolation and purification; pharynx; serotyping; transmission; virology; Capsid Proteins; Child, Preschool; Coxsackievirus Infections; Disease Outbreaks; Enterovirus; Female; Genotype; Hand, Foot and Mouth Disease; Herpangina; Humans; Incidence; Male; Pharynx; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sequence Analysis, DNA; Serotyping; Taiwan; Capsid Proteins; Child, Preschool; Coxsackievirus Infections; Disease Outbreaks; Enterovirus; Female; Genotype; Hand, Foot and Mouth Disease; Herpangina; Humans; Incidence; Male; Pharynx; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sequence Analysis, DNA; Serotyping; Taiwan |
顯示於: | 醫學檢驗暨生物技術學系 |
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