https://scholars.lib.ntu.edu.tw/handle/123456789/508255
標題: | The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats | 作者: | Hsieh S.-C. Lu C.-C. Horng Y.-T. Soo P.-C. Chang Y.-L. Tsai Y.-H. Lin C.-S. HSIN-CHIH LAI |
關鍵字: | 2,3-butanediol; Acute lung injury; Inflammation; LPS; NF-κB | 公開日期: | 2007 | 卷: | 9 | 期: | 12-13 | 起(迄)頁: | 1402-1409 | 來源出版物: | Microbes and Infection | 摘要: | Widely identified in bacteria, yeasts and human beings, 2,3-butanediol has been studied for decades.This chemical reportedly functions as a neutralization agent to counteract lethal acidification by bacterial growth and as a signaling molecule involved in interactions among insects, and between bacteria and the plant host. While 2,3-butanediol is produced by many pathogenic bacterial species, its significance and effect on mammals remains basically uncharacterized. Herein, we show that gastric intubation of 2,3-butanediol in rats significantly ameliorates acute lung injury (ALI) and the inflammatory responses induced by the bacterial endotoxin lipopolysaccharide (LPS), with an efficacy comparable to that of the polyphenol compound resveratrol. Such effect was further demonstrated to occur via modulation of the NF-κB signaling pathway. These results indicate that bacterial metabolite, 2,3-butanediol has a negative regulatory effect on host innate immunity response, suggesting bacteria may use some metabolites for host immune evasion. ? 2007 Elsevier Masson SAS. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/508255 | ISSN: | 1286-4579 | DOI: | 10.1016/j.micinf.2007.07.004 | SDG/關鍵字: | 2,3 butanediol; bacterium lipopolysaccharide; endotoxin; immunoglobulin enhancer binding protein; polyphenol; resveratrol; acidification; acute lung injury; animal experiment; animal model; animal tissue; article; bacterial growth; bacterial infection; controlled study; disease model; host pathogen interaction; host resistance; inflammation; male; nonhuman; priority journal; rat; signal transduction; Sprague Dawley rat; Animals; Anti-Inflammatory Agents; Butylene Glycols; Endotoxins; Inflammation; Lipopolysaccharides; Lung; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Bacteria (microorganisms); Hexapoda; Mammalia; Rattus |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。