https://scholars.lib.ntu.edu.tw/handle/123456789/508921
標題: | Guidelines and definitions for research on epithelial-mesenchymal transition | 作者: | Yang, Jing Antin, Parker Berx, Geert Blanpain, Cédric Brabletz, Thomas Bronner, Marianne Campbell, Kyra Cano, Amparo Casanova, Jordi Christofori, Gerhard Dedhar, Shoukat Derynck, Rik Ford, Heide L Fuxe, Jonas García de Herreros, Antonio Goodall, Gregory J Hadjantonakis, Anna-Katerina RUBY YUN-JU HUANG Kalcheim, Chaya Kalluri, Raghu Kang, Yibin Khew-Goodall, Yeesim Levine, Herbert Liu, Jinsong Longmore, Gregory D Mani, Sendurai A Massagué, Joan Mayor, Roberto McClay, David Mostov, Keith E Newgreen, Donald F Nieto, M Angela Puisieux, Alain Runyan, Raymond Savagner, Pierre Stanger, Ben Stemmler, Marc P Takahashi, Yoshiko Takeichi, Masatoshi Theveneau, Eric Thiery, Jean Paul Thompson, Erik W Weinberg, Robert A Williams, Elizabeth D Xing, Jianhua Zhou, Binhua P Sheng, Guojun |
公開日期: | 六月-2020 | 出版社: | NATURE PUBLISHING GROUP | 卷: | 21 | 期: | 6 | 起(迄)頁: | 341 | 來源出版物: | Nature reviews. Molecular cell biology | 摘要: | Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/508921 | ISSN: | 1471-0072 | DOI: | 10.1038/s41580-020-0237-9 | SDG/關鍵字: | molecular marker; carcinogenesis; cell plasticity; conceptual framework; consensus; epithelial mesenchymal transition; fibrosis; history of medicine; malignant neoplasm; medical research; medical terminology; practice guideline; priority journal; Review; animal; cell motion; developmental biology; human; medical research; neoplasm; nomenclature; pathology; Animals; Biomedical Research; Cell Movement; Cell Plasticity; Consensus; Developmental Biology; Epithelial-Mesenchymal Transition; Humans; Neoplasms; Terminology as Topic |
顯示於: | 醫學系 |
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