https://scholars.lib.ntu.edu.tw/handle/123456789/509436
Title: | Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients | Authors: | BANG-BIN CHEN CHAO-YU HSU CHIH-WEI YU Wei S.-Y. JIA-HORNG KAO Lee, Hsuan-Shu TIFFANY TING-FANG SHIH |
Issue Date: | 2012 | Journal Volume: | 22 | Journal Issue: | 1 | Start page/Pages: | 171-180 | Source: | European Radiology | Abstract: | Objectives To develop a non-invasive MRI method for evaluation of liver fibrosis, with histological analysis as the reference standard. Methods The study protocol was approved by the Institutional Review Board for Human Studies of our hospital, and written informed consent was obtained from all subjects. Seventy-nine subjects who received dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA were divided into three subgroups according to Metavir score: no fibrosis (n=30), mild fibrosis (n = 34), and advanced fibrosis (n = 15). The DCE-MRI parameters were measured using two models: (1) dual-input single- compartment model for arterial blood flow (F a), portal venous blood flow, total liver blood flow, arterial fraction (ART), distribution volume, and mean transit time; and (2) curve analysis model for Peak, Slope, and AUC. Statistical analysis was performed with Student'st-test and the nonparametric Kruskal-Wallis test. Results Slope and AUC were two best perfusion parameters to predict the severity of liver fibrosis (>F2 vs. ?F2). Four significantly different variables were found between non-fibrotic versus mild-fibrotic subgroups: F a, ART, Slope, and AUC; the best predictor for mild fibrosis was F a(AUROC:0.701). Conclusions DCE-MRI with Gd-EOB-DTPA is a noninvasive imaging, by which multiple perfusion parameters can be measured to evaluate the severity of liver fibrosis. ? European Society of Radiology 2011. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/509436 | ISSN: | 0938-7994 | DOI: | 10.1007/s00330-011-2249-5 | SDG/Keyword: | gadoxetic acid; adult; area under the curve; chronic hepatitis; contrast enhancement; controlled study; disease severity; distribution volume; female; hepatitis B; hepatitis C; histology; human; liver blood flow; liver fibrosis; major clinical study; male; nuclear magnetic resonance imaging; priority journal; prospective study; review; vein blood flow; Adult; Algorithms; Area Under Curve; Blood Flow Velocity; Contrast Media; Female; Gadolinium DTPA; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Magnetic Resonance Imaging; Male; Prospective Studies; ROC Curve; Sensitivity and Specificity; Severity of Illness Index |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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