https://scholars.lib.ntu.edu.tw/handle/123456789/510054
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | UN-IN WU | en_US |
dc.contributor.author | YU-CHUNG CHUANG | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | HSIN-YUN SUN | en_US |
dc.contributor.author | Jhong, Y. T. | en_US |
dc.contributor.author | JANN-YUAN WANG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | YEE-CHUN CHEN | en_US |
dc.date.accessioned | 2020-07-15T04:53:23Z | - |
dc.date.available | 2020-07-15T04:53:23Z | - |
dc.date.issued | 2018-02-01 | - |
dc.identifier.issn | 1198743X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/510054 | - |
dc.description.abstract | © 2017 European Society of Clinical Microbiology and Infectious Diseases Objective: Anti-interferon- γ (IFN-γ) autoantibodies (anti-IFN-γ Abs) have been increasingly recognized as an important cause of disseminated nontuberculous mycobacterial (DNTM) infection, and identification of this immunodeficiency impacts clinical management. However, the protean disease manifestations and inaccessibility to diagnostic tests in clinical settings hamper its early diagnosis. Here, we sought to determine whether QuantiFERON-TB Gold In-tube (QFT-GIT), a commercialized IFN-γ release assay, could be used to screen for neutralizing anti-IFN-γ Abs among previously healthy adults with DNTM infection. Methods: Non-HIV patients with DNTM infection were prospectively enrolled for the QFT-GIT assays. We measured their plasma concentration of anti-IFN-γ Abs and their neutralizing capacity through enzyme-linked immunosorbent assay and flow cytometry. We then analysed the correlation between QFT-GIT results and the presence of neutralizing anti-IFN-γ Abs among patients with and without previously recognized immunosuppression, respectively. Results: Irrespective of the autoantibody concentration or disease activity, all patients with neutralizing anti-IFN-γ Abs (100%, 30/30) had indeterminate QFT-GIT results because of extremely low or undetectable IFN-γ levels in the mitogen tubes. None of the four DNTM patients who were previously healthy and tested negative of anti-IFN-γ Abs had an indeterminate QFT-GIT result, and their IFN-γ levels in the mitogen tube were significantly higher than those of the patients with anti-IFN-γ Abs (8.28 IU/mL vs. 0.05 IU/mL, p 0.001). Conclusion: An indeterminate QFT-GIT result because of undetectable or extremely low IFN-γ level in the mitogen tube suggests the presence of neutralizing anti-IFN-γ Abs in a previously healthy patient with DNTM infection. | en_US |
dc.relation.ispartof | Clinical Microbiology and Infection | en_US |
dc.subject | Anti-IFN-γautoantibodies | Clinical utility | Disseminated NTM infections | IGRA | QuantiFERON | en_US |
dc.subject | Anti-IFN-γautoantibodies; Clinical utility; Disseminated NTM infections; IGRA; QuantiFERON | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | C reactive protein; gamma interferon; neutralizing antibody; STAT1 protein; autoantibody; gamma interferon; neutralizing antibody; adult; aged; antibody blood level; antibody detection; antibody screening; Article; clinical article; controlled study; disease activity; enzyme linked immunosorbent assay; female; flow cytometry; human; male; mycobacteriosis; Mycobacterium abscessus; Mycobacterium avium complex; Mycobacterium chelonae; Mycobacterium fortuitum; Mycobacterium gordonae; Mycobacterium kansasii; nonhuman; predictive value; priority journal; prospective study; atypical mycobacteriosis; immunology; interferon gamma release assay; middle aged; procedures; Adult; Aged; Antibodies, Neutralizing; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Interferon-gamma; Interferon-gamma Release Tests; Male; Middle Aged; Mycobacterium Infections, Nontuberculous | - |
dc.title | Use of QuantiFERON-TB Gold In-tube assay in screening for neutralizing anti-interferon-γ autoantibodies in patients with disseminated nontuberculous mycobacterial infection | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.cmi.2017.06.029 | - |
dc.identifier.pmid | 28694201 | - |
dc.identifier.scopus | 2-s2.0-85027467124 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85027467124 | - |
dc.relation.journalvolume | 24 | en_US |
dc.relation.journalissue | 2 | en_US |
dc.relation.pageend | 165 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.orcid | 0000-0001-8182-6071 | - |
crisitem.author.orcid | 0000-0003-3094-8276 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0003-0074-7721 | - |
crisitem.author.orcid | 0000-0003-3406-366X | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0002-1816-9010 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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